Registration Dossier
Registration Dossier
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EC number: 287-836-1 | CAS number: 85586-34-1
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
A 48 hour static, acute toxicity study was performed according to the DIN-Vorschrift 38412-L15 (static procedure) guideline. Leuciscus idus were exposed for 48 hours to nominal concentrations of TK 11278. Based on nominal exposure concentrations the 48 hour LC50 was calculated to be 900 mg/L, the corresponding no-observed effect concentration (NOEC) was 580 mg/L.
Key value for chemical safety assessment
Additional information
A 48 hour static, acute toxicity study was performed according to the DIN-Vorschrift 38412-L15 (static procedure) guideline. Leuciscus idus were exposed for 48 hours to nominal concentrations of TK 11278. Based on nominal exposure concentrations the 48 hour LC50 was calculated to be 900 mg/L, the corresponding no-observed effect concentration (NOEC) was 580 mg/L.
The water solubility of ESBO is estimated to be <0.02 µg/L, categorised as insoluble REACH. Ideally aquatic toxicity studies should not be conducted above the limit of water solubility, the study reported here tested nominal concentrations up to 1000 mg/L. According to Annex VIII a short-term test on fish is required unless there are mitigating factors such as the test substance is insoluble, this is the case for ESBO. Therefore, the fish study is reported here for information only (this study was also reported in the OECD SIDS Initial Assessment Report for SIAM 22, 18 -21 April 2006), the endpoint will not be used for PNEC setting or in any risk assessment.
ESBO forms the core of the structure of soybean oil, epoxidised, ether with ethylene glycol, which has similar low solubility in water. The ether linkages and attachment of ethylene glycol (which itself has low intrinsic toxicity to aquatic organisms, as shown in the summarised RIVM review paper) is not expected to modify the acute toxicity of soybean oil, epoxidised, ether with ethylene glycol significantly, compared to that of ESBO.
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