Reaction products of phosphoric acid, rock phosphate and humic acids, potassium salts

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Secondary data source The rationale to use data from individual constituents and components of the complex is explained in chapter 1 of the CSR and in the adjacent "read-across document

Data source

Reference

Reference Type:

review article or handbook

Title:

Goodman and Gilman's: The Pharmcological Basis of Therapeutics 11th ed., p. 1648-9

Author:

L. L. Brunton, ed.

Year:

2006

Bibliographic source:

McGraw-Hill Medical Publishing Division, New York

Materials and methods

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Phosphates

IUPAC Name:

Phosphates

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:

Phosphates are absorbed from the gastrointestinal tract as orthophosphate. The transport of phosphate from the lumen is an active, energy-dependent process, and there are factors that appear to modify the degree of its intestinal absorption. Vitamin D stimulates phosphate absorption, and this effect has been reported to precede the action of the vitamin on transport of calcium ion. In general, about two thirds of the ingested phosphate is absorbed from the gastrointestinal tract in adults. Absorbed phosphate is almost entirely excreted into the urine.

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): no data
Phosphates are absorbed from the gastrointestinal tract as orthophosphate. The transport of phosphate from the lumen is an active, energy-dependent process, and there are factors that appear to modify the degree of its intestinal absorption. Vitamin D stimulates phosphate absorption, and this effect has been reported to precede the action of the vitamin on transport of calcium ion. In general, about two thirds of the ingested phosphate is absorbed from the gastrointestinal tract in adults. Absorbed phosphate is almost entirely excreted into the urine.