Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 230-191-8 | CAS number: 6969-71-7
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- other: In silico prediction.
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- In silico prediction using DEREK.
DEREK is a knowledge-based expert system designed to apply structure-activity relationships to compounds for which little or no data exists and hence to aid in the assessment of their potential toxicity. The DEREK knowledge base contains a large number of rules that associate a chemical structure with one or more toxicity end points. When a structural alert is identified a reasoning programme assigns a probability to the expression of toxicity by the test compound. - GLP compliance:
- no
- Type of study:
- other: In silico prediction.
Test material
- Reference substance name:
- 1,2,4-triazolo[4,3-a]pyridin-3(2H)-one
- EC Number:
- 230-191-8
- EC Name:
- 1,2,4-triazolo[4,3-a]pyridin-3(2H)-one
- Cas Number:
- 6969-71-7
- Molecular formula:
- C6H5N3O
- IUPAC Name:
- [1,2,4]triazolo[4,3-a]pyridin-3(2H)-one
Constituent 1
Results and discussion
Any other information on results incl. tables
DEREK evaluation showed alert for skin sensitization judged “plausible” in mammals including humans.
The presence of a skin sensitization structural alert within a molecule indicates the molecule has the potential to cause skin sensitization.Whether or not the molecule will be a skin sensitizer will also depend upon its percutaneous absorption. Generally, small lipophilic molecules are more readily absorbed into the skin and are therefore more likely to cause sensitization.
Applicant's summary and conclusion
- Interpretation of results:
- other: alert, but plausible” in mammals including humans
- Conclusions:
- DEREK evaluation showed alert for skin sensitization judged “plausible” in mammals including humans.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
