Registration Dossier
Registration Dossier
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EC number: 406-760-3 | CAS number: 42221-52-3 2,3,4,5-TETRACHLORBENZOYLCHLORID
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- genetic toxicity in vitro
- Remarks:
- Type of genotoxicity: genome mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other:
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 84/449/EWG, B.14 (Ames-Test)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2,3,4,5-tetrachlorobenzoylchloride
- EC Number:
- 406-760-3
- EC Name:
- 2,3,4,5-tetrachlorobenzoylchloride
- Cas Number:
- 42221-52-3
- Molecular formula:
- C7HCl5O
- IUPAC Name:
- 2,3,4,5-tetrachlorobenzoyl chloride
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: sat TA 98, 100, 1535, 1537, 1538
- Metabolic activation system:
- S9-Leberfraktion von mit AROCLOR 1254 behandelten Ratten.
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 10 ... 5000 μg/plate
Concentration range in the main test (without metabolic activation): 10 ... 5000 μg/plate - Vehicle / solvent:
- Solvent: DMSO
- Details on test system and experimental conditions:
- Concentration of the test substance resulting in precipitation: 5000 μg/plate
Results and discussion
Test results
- Species / strain:
- other: bacteria, other: sat TA 98, 100, 1535, 1537, 1538
- Metabolic activation:
- with
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not determined
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation
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