Registration Dossier
Registration Dossier
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EC number: 274-713-2 | CAS number: 70643-20-8
Endpoint summary
Administrative data
Description of key information
For the purpose of REACH registration, read across with the analogue substance 2-(2,4-diaminophenoxy)ethanol dihydrochloride appears appropriate. When tested undiluted, IMEXINE OAJ (2-(2,4-diaminophenoxy)ethanol dihydrochloride) was not irritating to the rabbit skin. Imexine OAJ (2-(2,4-diaminophenoxy)ethanol dihydrochloride) was considered to be an irritant to rabbit eyes when tested undiluted.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
For the purpose of REACH registration, read across with the analogue substance 2-(2,4-diaminophenoxy)ethanol dihydrochloride appears appropriate. The skin irritation potential of the substance 2-(2,4-diaminophenoxy)ethanol dihydrochloride was assessed according to OECD guideline 404 in compliance to GLP. The day before application, the back area of test animals was clipped free of hair. A 0.5g sample of neat IMEXINE OAJ was applied to 6 cm2 of the right flank which was previously treated with 0.5 ml paraffin oil. The untreated left flank served as a control. The dressing was then removed and cutaneous reactions were assessed 1, 24, 48 and 72 hours after dressing removal. There were no cutaneous reactions apart from a slight erytherma observed in 1 animal at the 48 hour observation only. When tested undiluted, IMEXINE OAJ (2-(2,4-diaminophenoxy)ethanol dihydrochloride) was not irritating to the rabbit skin.
The eye irritation potential of the substance 2-(2,4-diaminophenoxy)ethanol dihydrochloride was assessed according to OECD guideline 405 in compliance to GLP. On day 1, a 100mg sample of neat Imexine OAJ was instilled in the conjunctival sac of the left eye of the animals. The eyes were not rinsed following instillation of the test item. The non-treated right eye served as a control. The ocular reactions were assessed 1, 24, 48 and 72 hours after instillation, as well as on day 8 and day 15. Marked ocular reactions were observed. They included moderate to marked chemosis and slight to moderate redness of conjunctivae, slight to moderate corneal opacification and slight iridal lesions. At the end of the study (day 15), similar though less marked ocular reactions were observed. Imexine OAJ (2-(2,4-diaminophenoxy)ethanol dihydrochloride) was considered to be an irritant to rabbit eyes when tested undiluted.
Effects on eye irritation: irritating
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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