2,6,6-trimethylbicyclo[3.1.1]heptane-3-carbaldehyde

Endpoint summary

Description of key information

LD50, rat, oral (gavage) = 2000 mg/kg (BASF AG, 1985)
Inhalation Hazard Test: No mortality was observed after inhalation of a highly saturated vapor-air-mixture for 7 hours in rats (BASF AG, 1986)

Additional information

Oral:

The key study was performed according to a BASF-internal method equivalent or similar to OECD guideline 401 (BASF AG, 1985). The test substance was administered as a solution in olive oil via gavage to five fasted Wistar rats per sex and dose at dose levels of 1000, 1470, 2150, and 3160 mg/kg bw followed by a 14-day observation period. The LD50 was determined to be 2000 mg/kg bw in males and females (ca. 1470 mg/kg bw in females, ca. 2850 mg/kg bw in males). Clinical symptoms comprised dyspnea, apathy, abnormal position, staggering atonia, paresis, pain relfex absent, corenal reflex absent, narcotic-like state, twitching, piloerection, diarrhea, erythema, exsiccosis, imbalance, and poor general state in bothe sexes. In addition, tremor and lacrimation was observed in female animals. At necropsy, general congestive hyperemia and dilated stomach filled with feed and liquid contents were observed in animals that died. no abnormalities were detected in the sacrificed animals.

Inhalation:

No mortality occured in an acute vapour inhalation study comparable to the inhalation hazard test described in the Annex of OECD Guideline 403 with acceptable restrictions (non-GLP, low number of animals). In this study 3 male and 3 female Wistar rats were exposed for 7 hours to the saturated vapour of the test substance. Clinical signs during exposure were an accelerated, in some animals intermittent, respiration, slight attempts to escape, wiping of snouts, and trembling in some animals. After exposure no clinical signs were observed. No mortality occurred during the 14-day post-exposure observation period. Nothing abnormal was detected in the organs at necropsy.