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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin corrosion: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
2013
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data from database with results from Corrositex tests.

Data source

Reference
Reference Type:
other: database
Title:
Corrositex database
Author:
Invitro International
Year:
2013
Bibliographic source:
Corrositex database, available via http://www.invitrointl.com/store/

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
Deviations:
not specified
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
tetramethylammonium pentahydrate
IUPAC Name:
tetramethylammonium pentahydrate
Constituent 2
Reference substance name:
10424-65-4
Cas Number:
10424-65-4
IUPAC Name:
10424-65-4
Test material form:
other: tetramethylammonium hydroxide pentahydrate
Details on test material:
Not specified

Results and discussion

In vitro

Results
Remarks on result:
positive indication of irritation

Any other information on results incl. tables

According to the Corrositex database TMAOH pentahydrate should be classified in ADR/DOT packing group II for transport, based on experimental test results. Criteria for classification in packing group II correspond with those for skin corrosive 1B.

Applicant's summary and conclusion

Interpretation of results:
Category 1B (corrosive)
Conclusions:
According to the Corrositex database, TMAOH pentahydrate should be classified as packing group II for transport (ADR/DOT) based on experimental results from Corrositex testing. Based on the fact that the criteria for packing group II are identical to the criteria for the classification as skin corrosive 1B from OECD guideline 435, TMAOH pentahydrate is classified as skin corrosive 1B.
Executive summary:

According to the Corrositex database, TMAOH pentahydrate should be classified as packing group II for transport (ADR/DOT) based on experimental results from Corrositex testing. Based on the fact that the criteria for packing group II are identical to the criteria for the classification as skin corrosive 1B from OECD guideline 435, TMAOH pentahydrate is classified as skin corrosive 1B.