Registration Dossier
Registration Dossier
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EC number: 201-073-3 | CAS number: 77-98-5
Endpoint summary
Administrative data
Description of key information
The substance analogue TMAH has been established to be corrosive, category 1B. In view of the high pH of TEAH aqueous solutions due to the hydroxide ion, a similar effect on skin is expected, thus TEAH, as well as the registered substance (TEAH 35% in water), are also considered to be corrosive to skin, category 1B.
Any eye irritation study is waived as the registered substance, as well as TEAH, are classified as corrosive to skin. Both are also classified as irritating to eyes with risk of serious damage to eyes, in accordance with the CLP Regulation.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation/corrosion
Two acute dermal toxicity tests are performed with the registered substance. In both studies, necrosis of the skin was observed.
The substance analogue TMAH has been established to be corrosive, category 1B. An acute dermal irritation /corrosion test according to OECD 404 with 2.38% TMAH in water was performed under GLP circumstances and an in vitro study according to OECD 435 with tetramethylammonium hydroxide pentahydrate.
In view of the high pH of TEAH aqueous solutions due to the hydroxide ion, a similar effect on skin is expected, thus TEAH, as well as the registered substance (TEAH 35% in water), are also considered to be corrosive to skin, category 1B.Eye irritation/corrosion
Any eye irritation study is waived based on the corrosiveness of the registered substance to the skin and based on the strong alkalinity of the substance.
Justification for selection of skin irritation / corrosion endpoint:
No key study was selected, the endpoint conclusion is derived by weight of evidence.
Justification for selection of eye irritation endpoint:
The study is waived, based on the corrosive properties of the substance.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
The substance analogue TMAH has been established to be corrosive, category 1B. In view of the high pH of TEAH aqueous solutions due to the hydroxide ion, a similar effect on skin is expected, thus TEAH, as well as the registered substance (TEAH 35% in water), are also considered to be corrosive to skin, category 1B.
In accordance with section 3.3.2.3 of Annex 1 of the CLP Regulation, the registered substance, as well as TEAH, are also classified as irritating to eyes with risk of serious damage to eyes.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
