Tetraethylammonium hydroxide

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

The test was performed with substance analogue TMAC. The rationale for read-across is attached in IUCLID section 13.

Reason / purpose for cross-reference:

read-across source

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

462 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: 431-495 mg/L

Details on results:

Number of organisms observed dead (Mortalities)
========================================
Nominal Concentrations (mg/L)
Hour ---------------------------------
0 157 242 372 573 882
----------------------------------------
24 0 0 0 1 11 12
48 0 0 0 1 11 14
72 0 0 0 3 14 16
96 0 0 1 3 17 17
========================================

Results with reference substance (positive control):

No data

Reported statistics and error estimates:

The estimated LC50 with corresponding 95% confidence intervals were calculated using the nominal tank concentrations and the Trimmed Spearman-Karber Method.

Validity criteria fulfilled:

not specified

Remarks:

the validity criteriumof feeding could not be checked as the data is not available.

Conclusions:

The 96h-LC50 of TMAC was determined to be 462 mg/L. This result is read across to TEAH.

Executive summary:

An acute fish test was carried out in a flow-through system according to a method similar to OECD203. No analytical measurements were performed. However, as the test was set up as flow-through, the test concentrations are kept stable. Furthermore, as the test substance is assumed to have a high water solubility, the actual test concentrations and nominal concentrations are deemed comparable. The 96h-LC50 of TMAC was determined to be 462 mg/L, based on nominal concentrations. This result is read across to TEAH.

Description of key information

The 96h-LC50 of the structural analogue TMAC to fish was determined to be 462 mg/L. Therefore it can be assumed that the 96h-LC50 of TEAH to fish exceeds 100 mg/L.

Additional information

The acute toxicity to fish has been investigated for the structural analogue TMAC (see read-across document attached in IUCLID section 13).

An acute fish test was carried out in a flow-through system according to a method similar to OECD203. No analytical measurements were performed. However, as the test was set up as flow-through, the test concentrations are kept stable. Furthermore, as the test substance is assumed to have a high water solubility, the actual test concentrations and nominal concentrations are deemed comparable. The 96h-LC50 of TMAC was determined to be 462 mg/L, based on nominal concentrations. Therefore it can be assumed that the 96h-LC50 of TEAH to fish exceeds 100 mg/L.