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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
The test was performed with substance analogue TMAC. The rationale for read-across is attached in IUCLID section 13.
Reason / purpose for cross-reference:
read-across source
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
462 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Remarks on result:
other: 431-495 mg/L
Details on results:
Number of organisms observed dead (Mortalities)
========================================
Nominal Concentrations (mg/L)
Hour ---------------------------------
0 157 242 372 573 882
----------------------------------------
24 0 0 0 1 11 12
48 0 0 0 1 11 14
72 0 0 0 3 14 16
96 0 0 1 3 17 17
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Results with reference substance (positive control):
No data
Reported statistics and error estimates:
The estimated LC50 with corresponding 95% confidence intervals were calculated using the nominal tank concentrations and the Trimmed Spearman-Karber Method.
Validity criteria fulfilled:
not specified
Remarks:
the validity criteriumof feeding could not be checked as the data is not available.
Conclusions:
The 96h-LC50 of TMAC was determined to be 462 mg/L. This result is read across to TEAH.
Executive summary:

An acute fish test was carried out in a flow-through system according to a method similar to OECD203. No analytical measurements were performed. However, as the test was set up as flow-through, the test concentrations are kept stable. Furthermore, as the test substance is assumed to have a high water solubility, the actual test concentrations and nominal concentrations are deemed comparable. The 96h-LC50 of TMAC was determined to be 462 mg/L, based on nominal concentrations. This result is read across to TEAH.

Description of key information

The 96h-LC50 of the structural analogue TMAC to fish was determined to be 462 mg/L. Therefore it can be assumed that the 96h-LC50 of TEAH to fish exceeds 100 mg/L.

Key value for chemical safety assessment

Additional information

The acute toxicity to fish has been investigated for the structural analogue TMAC (see read-across document attached in IUCLID section 13).

An acute fish test was carried out in a flow-through system according to a method similar to OECD203. No analytical measurements were performed. However, as the test was set up as flow-through, the test concentrations are kept stable. Furthermore, as the test substance is assumed to have a high water solubility, the actual test concentrations and nominal concentrations are deemed comparable. The 96h-LC50 of TMAC was determined to be 462 mg/L, based on nominal concentrations. Therefore it can be assumed that the 96h-LC50 of TEAH to fish exceeds 100 mg/L.