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EC number: 942-100-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 08, 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- no
- GLP compliance:
- no
- Test organisms (species):
- activated sludge
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Test temperature:
- 20.9 °C
- pH:
- 7.6
- Dissolved oxygen:
- 0.66 - 0.80 mg O2 pro min/l
- Nominal and measured concentrations:
- 10, 32, 100, 320 mg/l
- Reference substance (positive control):
- yes
- Remarks:
- 3.5 Dichlorphenol
- Duration:
- 3 h
- Dose descriptor:
- IC50
- Effect conc.:
- > 320 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Results with reference substance (positive control):
- IC50 (reference substance) = 9.2 mg/l
- Validity criteria fulfilled:
- not specified
- Conclusions:
- IC50 (3h) > 320.0 mg/l
- Executive summary:
The substance to be registered has been tested according to OECD 209, during the test the IC50 have been evaluated both for the test substance and for the 3,5 -dichlorophenol, used as reference substance.
For the test item IC50 > 320.0 mg/l, for the reference substance IC50 = 9.4.
Reference
Control values:
control | pH(3h) | O2 - Consumption | Time | mgO2 pro min/l | ||
K1 | 7.8 | 3.2 | 3.1 | 0.83 | K1/K2 = 0.67% | ΦK = 0.79 |
K2 | 7.4 | 3 | 3.2 | 0.75 | K2/K1 = 9.64% |
Test substance values:
test substance | pH(3h) | O2 - Consumption | Time | mgO2 pro min/l | comparison with ΦK (%) | Consumption (%) |
320 | 7.6 | 3.3 | 4.0 | 0.66 | 83.54 | 16.46 |
100 | 7.6 | 4.0 | 4.4 | 0.73 | 92.41 | 7.59 |
32 | 7.6 | 3.6 | 3.6 | 0.80 | 101.27 | 0.00 |
10 | 7.6 | 3.8 | 3.9 | 0.78 | 98.73 | 1.27 |
Reference substance values:
3.5 - dichlorophenol (mg/l) | pH(3h) | O2 - Consumption | Time | mgO2 pro min/l | comparison with ΦK (%) | Consumption (%) |
32 | 7.6 | 0.8 | 4.9 | 0.13 | 16.46 | 83.54 |
10 | 7.5 | 1.9 | 4.2 | 0.36 | 45.57 | 54.43 |
3.2 | 7.5 | 3.7 | 4.5 | 0.66 | 83.54 | 16.46 |
Description of key information
Freshwater: IC50 (3h) > 320.0 mg/l
Key value for chemical safety assessment
- EC50 for microorganisms:
- 320 mg/L
Additional information
Three studies are available for the toxicity to microorganisms but only the Huntsman one (1994) contains sufficient details to be considered reliable to be choose as key study. The other two are short abstracts which results are in agreement with the key study result. The key value for the risk assessment has been set as IC50 > 320 mg/l.
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