Registration Dossier
Registration Dossier
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EC number: 941-032-3 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
The oral LD50 of:
- isovaleraldehyde (CAS 590-86-3) was determined to be 5740 mg/kg bw in male and female rats (BASF, 1974).
- 3-methyl-1-butanol (CAS 123-51-3) was determined to be > 5000 mg/kg bw in Sprague-Dawley rats (BASF, 1979).
- 3-Buten-1-ol, 3-methyl- (CAS 763-32-6) was determined to be > 5440 mg/kg bw in Sprague-Dawley rats (BASF, 1968).
- 3-Methyl-butandiol-1,3 (CAS 2568-33-4) was determined to be > 5000 mg/kg bw in Sprague-Dawley rats (BASF, 1979) based on the read across to 3-methyl-1-butanol (CAS 123-51-3).
- 2H-Pyran, tetrahydro-4-methyl-2-(2-methylpropyl)- (CAS 13477-62-8) was determined to be > 5000 mg/kg bw in Wistar rats (BASF, 1983).
- Rose oxide (EC 939-429-1) was determined to be > 2000 mg/kg bw (Symrise, 2001) and was used as read across for DHP1, DHP2 and DHP3.
- 2H-Pyran-4-ol, tetrahydro-4-methyl-2-(2-methylpropyl)- (CAS 63500-71-0) was determined to be > 2000 mg/kg bw in Sprague-Dawley rats (Givaudan, 1992)
Available data on acute inhalation toxicity:
- isovaleraldehyde (CAS 590-86-3): LC50 = 42.7 mg/L in rats (Carpenter, 1974).
- 3-methyl-1-butanol (CAS 123-51-3): LC0 = 11.05 mg/L air (saturated vapour, 7h) in Sprague-Dawley rat (BASF, 1981). EU classification according to Annex VI of Directive 67/548/EEC: Xn, Harmful by inhalation; GHS classification (Regulation (EC) No 1272/2008 (CLP)): legal classification H332 Harmful if inhaled, Acute tox. inhalation Cat. 4.
- 3-Buten-1-ol, 3-methyl- (CAS 763-32-6): LC0 = 21.5 mg/l (saturated atmosphere at 20 °C, 8 h) in rats (BASF, 1968).
- 3-Methyl-butandiol-1,3 (CAS 2568-33-4): LC0 = 11.05 mg/L air (saturated vapour, 7h) in Sprague-Dawley rat (BASF, 1981) based on theread across to 3-methyl-1-butanol (CAS 123-51-3).
- 2H-Pyran, tetrahydro-4-methyl-2-(2-methylpropyl)- (CAS 13477-62-8): LC0 = 23.1 mg/l (saturated vapour, 7h) in Wistar rats (BASF, 1993).
The dermal LD50 of:
- isovaleraldehyde (CAS 590-86-3): 2534 mg/kg bw in male rabbits (Carpenter, 1974).
- 3-methyl-1-butanol (CAS 123-51-3) was determined to be approx. 3216 mg/kg bw in New Zealand white rabbits (Smyth, 1969).
- 3-Methyl-butandiol-1,3 (CAS 2568-33-4) was determined to be approx. 3216 mg/kg bw in New Zealand white rabbits (Smyth, 1969) based on the read across to 3-methyl-1-butanol (CAS 123-51-3).
- 2H-Pyran, tetrahydro-4-methyl-2-(2-methylpropyl)- (CAS 13477-62-8) was determined to be > 2000 mg/kg bw in Wistar rats (BASF, 1984).
- Rose oxide (EC 939-429-1) was determined to be > 5000 mg/kg (Moreno 1973) and was used as read across for DHP1, DHP2 and DHP3.
- 2H-Pyran-4-ol, tetrahydro-4-methyl-2-(2-methylpropyl)- (CAS 63500-71-0) was determined to be > 2000 mg/kg bw in rabbit (Firmenich, 1985).Justification for classification or non-classification
The present data on acute oral, inhalation and dermal toxicity do not fulfill the criteria laid down in 1999/45/EG and regulation (EU) 1272/2008, and therefore, a non-classification for the UVCB substance Reaction products of 3-methylbutanal and 3-methylbut-3-en-1-ol, distillation overheads, acid-treated, hydrogenated is warranted.
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