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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to Guideline study. Only basic data given.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1983
Report date:
1983

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
Limited information concerning test conditions and/or experimental methods.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
Sodium dodecyl sulphate
EC Number:
205-788-1
EC Name:
Sodium dodecyl sulphate
Cas Number:
151-21-3
IUPAC Name:
sodium dodecyl sulfate
Details on test material:
- Name of test material (as cited in study report): Sodium laurylsulfate
- Physical state: White powder
- Analytical purity: >98% a.i.
- Lot / Batch No. : 68/3
- Storage condition of test material: No data

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female
Details on test animals or test system and environmental conditions:
According to guideline.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
no data
No. of animals per sex per dose:
5-10
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 200 mg/kg bw
Based on:
test mat.
Sex:
female
Dose descriptor:
LD50
Effect level:
977 mg/kg bw
Based on:
test mat.
Sex:
male
Dose descriptor:
LD50
Effect level:
1 427 mg/kg bw
Based on:
test mat.
Mortality:
Occurred, but no detailed data.
Clinical signs:
other: Diarrhoea, spastic gait, decreased activity, lateral position, hunched posture, laboured respiration, coma, death.
Gross pathology:
Necropsy of died animals: haemorrhages in gastro-intestinal tract and vascular congestion in the liver
Necropsy of survivors: no adverse effects
Other findings:
Not stated.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU