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EC number: 700-066-7 | CAS number: 1472633-72-9
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- Ecotoxicological Summary
- Aquatic toxicity
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- Short-term toxicity to fish
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Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The 34 day NOEC based on fish mortality, length, weight and condition was considered to be 5.6 mg B/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 5.6 mg/L
Additional information
The reference substance (BAGE) hydrolyses within less than an hour to its hydrolysis products: Boric acid and glycerol. Therefore, conducting a long-term fish study on the reference substance itself was considered not to be feasible. If a study was conducted on the reference substance, it would give a result representative of the hydrolysis products mentioned above.
Boric acid is considered to be the hydrolysis product of main concern. An assessment of boric acid has therefore been made based on available long-term fish study data.
Boric acid
Hooftman et al 2000 Brachydanio rerio:
A study was conducted according to OECD Guideline 210 (Fish, Early-Life Stage Toxicity Test).
Brachydanio rerio fertilized eggs/embryos were exposed in a semi-static system for 34 days to the following nominal concentrations of boric acid: Control (0), 0.18, 0.56, 1.8, 5.6, 18, 56 mg B/L.
The 34 day NOEC based on fish mortality, length, weight and condition was considered to be 5.6 mg B/L based on the results of the study.
Using multiple statistical approaches, the data for egg hatch, mortality and fish length are consistent in showing statistical effects at exposures of 18 mg B/L and above. The exposures ranging from 0.18 to 5.6 mg B/L were not statistically different from each other. The statistical review concluded that the 5.6 mg B/L group should be considered to be the NOEC based on multiple statistical approaches.
Glycerol
Glycerol is the other hydrolysis product of the reference substance, BAGE. It is not classified for the environment according to CLP or DSD.
Available data (see section 13) suggests that glycerol is of low toxicity to fish.
Refer to section 13, Ecotoxicological expert report (BAGE: Evaluation of Environmental Fate and Ecotoxicity Properties) for further details of the evalaution of ecotoxicological properties of the reference substance and its hydrolysis products, especially for additional information on glycerol.
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