Registration Dossier
Registration Dossier
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EC number: 942-400-6 | CAS number: -
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
QSARs models, Biowin v4.10 and CATALOGIC Kinetic 301F v.11.14, WoE, validity 2:
Not readily biodegradable
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
To assess the ready biodegradability of the registered substance, no experimental studies were performed but estimated data were obtained from two reliable QSAR models and were used in a weight of evidence approach.
The first model used is Biowin v4.10, plug-in from EPISUITE v4.1 from US EPA. This model is recommended by the ECHA guidance document on information requirements and is well documented with regard to validation parameters according to OECD principles. Moreover, the substance is fully characterised towards the applicability domain. The Biowin 3 result is "weeks" but the Biowin 5 probability is less than 0.5; therefore the prediction is not readily biodegradable. In addition, Biowin 6 also predict not readily biodegradable, corresponding to a degradation in the OECD 301C test. In conclusion, it's expected that the substance is not readily biodegradable.
The second model is CATALOGIC Kinetic 301F v.11.14, plug-in from OASIS CATALOGIC v.5.11.15. This model is well documented with regard to validation parameters according to OECD principles. Moreover, the substance is fully characterised towards the applicability domain. According to the results of this prediction (Biological Oxygen Demand, BOD (28d) = 0.03), the substance is also expected to be not readily biodegradable in the OECD 301F test conditions.
In conclusion, based on the same predictions obtained between these two QSAR models, the registered substance can be considered as not readily biodegradable.
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