Registration Dossier
Registration Dossier
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EC number: 233-036-2 | CAS number: 10025-67-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The single in-vitro bacterial mutagenicity test conducted with disulphur dichloride was negative.
Further in vitro testing is scientifically not justified, as disulphur dichloride (S2Cl2) undergoes rapid hydrolysis to give hydrochloric acid (HCl), sulphur dioxide (SO2), and thiosulphate (S2O32-) as main products. Neither product has mutagenic properties in vitro or in vivo. In aqueous cell culture medium SO2 is in equilibrium with the sulfite ion which is oxidised to sulfate by sulfite oxidase in the mitochondria; hydrochloric acid will dissociate in an aqueous milieu, as well, and the resulting chloride ion also plays an important physiological role. Thiosulphate is also an endogenous anion in the human body with no potential health hazard. Thus, cell cultures treated with S2Cl2 will be exposed to hydrolysis products that can exert a pH effect on cell viability but in buffered solutions only harmless physiological ions will be formed. In-vitro genotoxicity studies with S2Cl2 in mammalian cells are therefore superfluous.
Short description of key information:
Ames test: negative
In vitro cytogenicity in mammalian cells (or in vitro micronucleus study) and in vitro gene mutation study in mammalian cells: waiving
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Conclusive, but not sufficient for classification.
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