Registration Dossier
Registration Dossier
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EC number: 228-391-5 | CAS number: 6258-06-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The test substance is an odourless, red solid/powder with a molecular weight of 404.17 g/mol and a log Pow of -0.53 at 25°C. Its water solubility is about 20 g/L at 15 - 20°C.
In two acute oral toxicity study, rats were treated orally with the test substance at 5000 and 20000 mg/kg bw. Clinical signs or deaths were not reported. In two subacute oral toxicity studies, male and female rats were treated with the test substance at concentrations of 40 – 1000 mg/kg bw. At 200 mg/kg bw slight hepatocytomegaly, hyaline droplets and intraepithelial eosinophilic cytoplasmic inclusions in the tubulus epithelium were observed in the male rats. At 1000 mg/kg bw reduced weight gain, reduced food intake, reduced erythrocyte count, reduced haemoglobin and haematocrit content, increased spleen weight, congestion, increased extramedullary hematopoiesis were observed in male and female animals (Bayer 21366). In the second study, no death was observed, but from 3rd week of treatment, squatting position, decreased food intake and a decrease of mean body weights by up to 12 % were observed. Clinical signs that were obvious in the first study indicate that absorption of the test substance along the gastro intestinal tract and hence systemic exposure is possible. This assumption is supported by the physico-chemical parameters of the test substance: a molecular weight below 500, the hydrophilic properties, the sulphonate functional group and hence the good water solubility are favourable for GIT-absorption (ECHA, R7c).
Dermal uptake might be unlikely with regard to the molecular weight of the test substance, and anticipated to be low to moderate with regard to the water solubility. Furthermore, the log Pow indicates poor lipophilicity which limits penetration into the stratum corneum and hence dermal absorption (ECHA, R7c). In addion, irritating effects of the test substance were not observed (damage to the skin surface may enhance penetration) (Bayer 1979, Marhold 1972).
No data on inhalative toxicity of the test substanceis available, but the log Pow of -0.53 favours absorption across the respiratory tract epithelium by passive diffusion. On the other hand, the hydrophilic properties of the test substance are indicative for retention within the mucus.
Overall, the substance is considered to be non bioaccumulating.
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