Registration Dossier
Registration Dossier
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EC number: 218-336-3 | CAS number: 2123-24-2
Endpoint summary
Administrative data
Description of key information
Fish toxicity, freshwater, acute: LC50 > 100 mg/L
Invertebrates toxicity, freshwater, acute: EC50 > 500 mg/L
Invertebrates toxicity, freshwater, long-term: NOEC = 100 mg/L
Algae toxicity, freshwater, acute: EC50 > 1.000 mg/L
Toxicity to micororganisms, activated sludge, acute: EC10 = 125 mg/L
Additional information
Data obtained by Read-Across from ε-caprolactam:
As key study for PNEC derivation the chronic study concerning toxic effects of epsilon-Caprolactam on invertebrates was identified. From the NOEC of 100 mg/l the PNEC was derived. For the PNEC STP the NOEC of the OECD 209 study of 125 mg/l was used for further risk assessment.
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Data obtained by Read-Across from sodium hydroxide:
At concentrations reported in publications and study reports, the toxicity has been assumed to be
due to hydroxide only, because at these effect concentrations the concentration of sodium is too low
to explain the effects. However, it should be realised that the results of toxicity tests with NaOH
depend on the buffer capacity of the test medium. In a highly buffered test medium the hydroxyl ion
will be neutralized and the observed toxicity will be low, while in a poorly buffered test medium the
pH will increase rapidly and therefore the observed toxicity will be relatively high (see also section
2.1). Besides the direct effects (pH change) NaOH could also have indirect effects. The pH change
could influence the speciation of other chemicals and therefore increase and/or decrease the toxicity
e.g. NH3 is more toxic than NH4 +.
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