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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
experimental data of read across substances
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two hydrolysis studies as-
2.. and 3.
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
not specified
pH:
7
Temp.:
25 °C
Remarks:
2. Other details not known
Temp.:
27 °C
Remarks:
3. Other details not known
Positive controls:
not specified
Negative controls:
not specified
Transformation products:
not specified
pH:
7
Temp.:
25 °C
DT50:
9 d
Remarks on result:
other: 2. Neutral hydrolysis rate constant is 0.0032/hr, respectively.
Temp.:
27 °C
Remarks on result:
other: 3. Chemical was reported to undergo slow hydrolysis in water.
Details on results:
2. The half-life value of test chemical was determined to be 9 days (216 hrs) at a pH range of 7 and at a temperature of 25°C, respectively
3. Although half-life value of test chemical was not known, but chemical was reported to undergo slow hydrolysis in water at a temperature of 27°C.
Validity criteria fulfilled:
not specified
Conclusions:
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be 9 days, at pH 7 and a temperature of 25-27°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is slowly hydrolysable in water.
Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical.The studies are as mentioned below:

The neutral hydrolysis rate constant and half-life value of test chemical was determined at a pH 7. The neutral hydrolysis rate constant of test chemical was determined to be 0.0032/hr, respectively with a corresponding half-lives of 9 days at pH 7 and at a temperature of 25°C, respectively. Based on the half-life value, it is concluded that the test chemical is slow hydrolysable in water.

In an another study, the neutral hydrolysis rate constant and half-life value of test chemical was determined at a temperature of 27°C. Although half-life value of test chemical was not known, but test chemical was reported to undergo slow hydrolysis in water.

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be 9 days, at pH 7 and a temperature of 25-27°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is slowly hydrolysable in water.

Description of key information

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be 9 days, at pH 7 and a temperature of 25-27°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is slowly hydrolysable in water.

Key value for chemical safety assessment

Half-life for hydrolysis:
9 d
at the temperature of:
25 °C

Additional information

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical. The studies are as mentioned below:

 

The neutral hydrolysis rate constant and half-life value of test chemical was determined at a pH 7. The neutral hydrolysis rate constant of test chemical was determined to be 0.0032/hr, respectively with a corresponding half-lives of 9 days at pH 7 and at a temperature of 25°C, respectively. Based on the half-life value, it is concluded that the test chemical is slow hydrolysable in water.

 

In an another study, the neutral hydrolysis rate constant and half-life value of test chemical was determined at a temperature of 27°C. Although half-life value of test chemical was not known, but test chemical was reported to undergo slow hydrolysis in water.

 

On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be 9 days, at pH 7 and a temperature of 25-27°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical is slowly hydrolysable in water.