Registration Dossier
Registration Dossier
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EC number: 929-513-6 | CAS number: 1400584-86-2
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- sodium (5s,8s)-8-methoxy-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-ide
- EC Number:
- 929-513-6
- Cas Number:
- 1400584-86-2
- Molecular formula:
- C9H13N2O3 · Na
- IUPAC Name:
- sodium (5s,8s)-8-methoxy-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-ide
- Test material form:
- solid: bulk
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficientopen allclose all
- Type:
- Pow
- Partition coefficient:
- 0.8
- Temp.:
- 22.7 °C
- pH:
- 2
- Key result
- Type:
- log Pow
- Partition coefficient:
- -0.1
- Temp.:
- 22.7 °C
- pH:
- 2
- Type:
- Pow
- Partition coefficient:
- 0.03
- Temp.:
- 22.7 °C
- Remarks on result:
- other: distilled water
- Type:
- log Pow
- Partition coefficient:
- -1.5
- Temp.:
- 22.7 °C
- Remarks on result:
- other: distilled water
Applicant's summary and conclusion
- Conclusions:
- The partition coefficients (1-octanol / water) of the test item were: log Pow = -1.5 destilled water
- Executive summary:
The partition coefficients 1-octanol / water of the test item at pH 2 and in distilled water at room temperature were determined according to the "shake flask method" described in EEC Test Guideline 92/69 A.8, OECD Test Guideline 107 and EPA Product Properties Test Guideline OPPTS 830.7550.
The partition coefficients (1-octanol / water) of the test item were:pH 2 distilled water POW 0.8 0.03 log POW -0.1 -1.5
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