Registration Dossier
Registration Dossier
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EC number: 203-727-3 | CAS number: 110-00-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment. Toxicity report giving very brief summary of this and other studies.
Data source
Reference
- Reference Type:
- publication
- Title:
- Respiratory retention and acute toxicity of furan
- Author:
- Egle JL; Gochberg BJ
- Year:
- 1 979
- Bibliographic source:
- Am Ind. Hyg. Assoc. 40, 310-314
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
- Test type:
- fixed concentration procedure
- Limit test:
- no
Test material
- Reference substance name:
- Furan
- EC Number:
- 203-727-3
- EC Name:
- Furan
- Cas Number:
- 110-00-9
- Molecular formula:
- C4H4O
- IUPAC Name:
- furan
- Details on test material:
- No data.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 18-21 grams
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- System of generating particulates/aerosols: The furan used in the study was generated for inhalation by passing air through pure furan at room temprature. The vapour, in concentrated form was then transferred using 100 cc siliconized glass syringe to a 5.2 litre sealed glass desiccator containing 3 or 4 mice.
TEST ATMOSPHERE
- Brief description of analytical method used: Air samples containing the test substance were drawn from into syringes and analyzed in a GC. A 0.2ul aliquot of the vapour in solvent was injected into a Chromosob W column. Peak area was the main method used in compound identification and concnetration of vapour.
- Samples taken from breathing zone: yes - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 1 h
- Concentrations:
- 0.03 ug/mL to 1.0 ug/mL
- No. of animals per sex per dose:
- 3-4
- Control animals:
- not specified
- Details on study design:
- No data
Results and discussion
Effect levels
- Dose descriptor:
- LC50
- Effect level:
- 0.12 other: ug/ml
- Remarks on result:
- other: (0.11-0.13)
- Clinical signs:
- other: Those mice that did not survive became hyperactive for periods of 10 to 15 minutes, then their breathing laboured, and they died soon after.
- Gross pathology:
- Examination of the lungs revealed inflammation and fluid accumulation.
Applicant's summary and conclusion
- Conclusions:
- A very limited summary of a non-guideline, non-GLP study, recorded a 1-hour LC50 of 0.12 mg/l in small groups of mice exposed the furan vapour.
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