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Diss Factsheets
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EC number: 309-643-4 | CAS number: 100656-54-0 The product obtained by acid leaching of copper speiss. Composed primarily of antimony, arsenic and lead with high precious metal content.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://www.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no GLP (but other Quality Assurance); software
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- other: software
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
- Principles of method if other than guideline:
- Aquatic toxicity of the UVCB substance was determined by classifying based on Mixture rules from EU CLP ( Higher Tier= Additivity/Toxic Units of components eluted via Transformation/dissolution test to derive Hazard class) and back calculation to the corresponding L(E)C50 range
- GLP compliance:
- not specified
- Remarks:
- (other Quality Assurance was applied)
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- Typical across industry as defined in IUCLID 1.2.
Constituent 1
Test organisms
- Test organisms (species):
- other: Standard species relevant to environmental classification
Study design
- Test type:
- other: Standard tests relevant to environmental classification
- Total exposure duration:
- 48 h
Test conditions
- pH:
- pH 6
Results and discussion
Effect concentrations
- Remarks on result:
- other: Results determined based on elemental composition and T/D tests
- Details on results:
The Higher Tier Arche Tool CLP was run using available data from elemental composition (each as Total % constituent) and information from Transformation/dissolution tests (% element released) and compared to the ecotoxicity reference values of the relevant metals.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Result can be used to predict EC50 for crustacea and determine Classification of the UVCB substance. See Section 2 for potential resulting classifications.
- Executive summary:
The study provides a conservative estimate of the EC50 (for crustacea), derived on basis of the Classification outcome (Mixture toxicity rules) from the worst case typical elemental compositions across the industry as defined in IUCLID section 1.2 and 1.4).
The result is applicable to all intermediates that fall under the defined concentration ranges (IUCLID section 1.2).
Validity of the model used:
- Defined end points: aquatic toxicity (acute & chronic)
- Unambiguous algorithm from EU CLP Guidance:summation/additivity formula to determine Classification and, back-calculation to related hazard criteria
- Applicability domain: applicable to classify complex metal containing materials in a Tiered approach (see EU CLP Guidance pg 499 Annex IV.5.5, and for conceptual outline ICMM Fact Sheet “Ores & Concentrates – An industry approach to EU hazard classification”, Nov 2009). Available input information: elemental composition, representative mineralogical information and Transformation/dissolution (Higher Tier, includes correction for bioavailability).
- Mechanistic interpretation - metal-ion additivity: (1) The additivity assumption for the toxicity of mixtures of metals was evaluated by De Schamphelaere (2009) - in JAB Bass et al. in "Environmental Quality Standards for trace metals in the aquatic environment", UK Environment Science Report 2009 (Appendix 2): No clear conclusions could be made from the literature review but a targeted experimental design with aquatic algae, showed that the additivity mode could predict the toxicity of metal mixture: the toxicity of simultaneous Cu, Zn, Ni, Cd and Pb additions to two distinct surface waters could be predicted by the additive toxic unit approach. (2) A. Stockdale, E Tipping, S Lofts & SJ Ormod, combined metal speciation to the additive toxicity approach and predicted the combined metal toxicity in a range of UK river systems impacted by metals: in "Modelling multiple metal toxic effects in the field - evaluation of the Toxicity Binding Model (TBM)", ICA Report November 2009.
Adequacy of prediction: the substance falls within the applicability domain described above and, therefore, the predicted value can be considered as reliable. The prediction is moreover conservative as the highest release rates obtained for the T/D at pH6 were used as a translator across the industry. Same conclusions apply to the prediction of the Aquatic toxicity value.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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