Pyridinium, 1-butyl-, .mu.-chlorohexachlorodialuminate(1-) (1:1)

Skin irritation / corrosion

Administrative data

Endpoint:

skin corrosion: in vitro / ex vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2006/05/04-2006/07/31

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: This study was performed according to GLP and the methods applied are fully compliant with OECD TG 435.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2006

Report date:

2006

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)

Version / remarks:

(Corrositex)

Principles of method if other than guideline:

NA

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

N-butylpyridinium heptachlorodialuminate

IUPAC Name:

N-butylpyridinium heptachlorodialuminate

Details on test material:

Chemical Name: N-butylpyridinium heptachlorodialurninate
Description brown viscous liquid
Batch number C3319-I8
Date received 04 April 2006
Storage conditions room temperature in the dark, over silica gel, under nitrogen

Test animals

Species:

other: in vitro test

Strain:

other: in vitro test

Details on test animals or test system and environmental conditions:

NA

Test system

Type of coverage:

other: in vitro test

Preparation of test site:

other: in vitro test

Controls:

not required

Amount / concentration applied:

NA

Duration of treatment / exposure:

NA

Observation period:

NA

Number of animals:

NA

Details on study design:

NA

Results and discussion

In vitro

Results

Irritation / corrosion parameter:

other: Breakthrough Time

Run / experiment:

1

Value:

32

Vehicle controls validity:

valid

Negative controls validity:

valid

Positive controls validity:

valid

In vivo

Irritant / corrosive response data:

NA

Other effects:

NA

Any other information on results incl. tables

	Vial 1	Vial 2	Vial 3	Vial 4
Start time (hh:mm:ss)	00:00:00	00:06:00	00:07:00	00:08:00
Detection time (hh:mm:ss)	00:32:00	00:38:00	00:39:00	00:40:00
Breakthrough time (hh:mm:ss)	00:32:00	00:32:00	00:32:00	00:32:00

Applicant's summary and conclusion

Interpretation of results:

corrosive

Remarks:

Migrated information Criteria used for interpretation of results: other: US DOT Packaging Group Criteria

Conclusions:

Under the conditions of the test the test material was considered to be CORROSIVE and assigned the US DOT Packing Group Criteria II. According to GHS criteria, the test material was considered to CORROSIVE and assigned to the corrosive subcategory 1B.

Executive summary:

Introduction.

The test material was assessed for its corrosivity potential using the CORROSITEX assay.

Method.

The assay consisted of::

I) a qualification screen with the Chemical Detection System

II) a categorisation screen to identify test materials as having either a high or low acid/alkaline reserve

III) a definitive CORROSITEX assay

Results.

Sample qualified: YES

Sample category: I

Mean Breakthrough time: approximately 32 minutes

Conclusion.

Under the conditions of the test the test material was considered to be CORROSIVE and assigned the US DOT Packing Group Criteria II. According to GHS criteria, the test material was considered to CORROSIVE and assigned to the corrosive subcategory 1B.