Registration Dossier
Registration Dossier
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EC number: 282-762-6 | CAS number: 84418-50-8
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- other: survey
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: survey of exisiting occupational asthma cases
Data source
Reference
- Reference Type:
- other: Survey
- Title:
- Survey of existing occupational asthma cases related to Naphthenic acids, zinc salts, basic (CAS: 84418-50-8)
- Author:
- EBRC Consulting GmbH
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
- Type of sensitisation studied:
- respiratory
- skin
- Study type:
- survey
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- A questionnaire was developed focussing on the potential of Naphthenic acids, zinc salts, basic to cause respiratory (and skin) sensitisation.
Test material
- Reference substance name:
- Naphthenic acids, zinc salts, basic
- EC Number:
- 282-762-6
- EC Name:
- Naphthenic acids, zinc salts, basic
- Cas Number:
- 84418-50-8
- Molecular formula:
- Not available
- IUPAC Name:
- zinc(2+) bis(3-(3-ethylcyclopentyl)propanoate)
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not applicable
- Subjects:
- - Number of workers exposed: 38 workers (in 2019)
- Clinical history:
- - Number of workers undergo regular health surveillance: 38 workers (in 2019); 143 workers (last decade)
- Number of workers undergo regular lung function testing: 31 workers (in 2019); 130 workers (last decade)
Results and discussion
- Results of examinations:
- - Number of workers with respiratory sensitisation symptoms: 0 (in 2019), 0 (last decade)
- Number of workers with dermal sensitisation (allergic contact dermatitis): 0 (in 2019), 0 (last decade)
- Number of workers diagnosed with non-occupational exposure: 0 (in 2019), 0 (last decade)
- Number of workers with impaired lung function: 0 (in 2019), 0 (last decade)
Applicant's summary and conclusion
- Conclusions:
- Three companies that represent all registrants of the substance in Europe responded to the questionnaire. Currently, a total of 38 workers are involved in the handling and/or processing of the substance in Europe. None of these workers show symptoms of occupational asthma and/or dermal sensitisation. All workers are also handling other substances that are classified as respiratory sensitisers. In total, 143 workers underwent medical surveillance during the last decade, again without any clinical signs of respiratory sensitisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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