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Description of key information

The substance diaminomethylcyclohexane (MDACH) was tested to assess an androgenic and/or antiandrogenic activity by using the Yeast Androgen Screening Assay (YAS-Assay) with the hAR yeast strain. Under the experimental conditions chosen here, it is concluded that MDACH did neither exert androgenic effects nor antiandrogenic effects in the Yeast Androgen Screening (YAS) assay using the hAR yeast strain. [BASF, 2012]

Additional information

ANDROGENICITY:

An increase in the androgen receptor dependent enzyme expression (color development)

was not observed.

ANTIANDROGENICITY:

A reproducible inhibition of the androgen effect compared to 5*10^-09 mol/L 5α-dihydrotestosterone (partly or total suppression of expected color development) was not observed.

According to the results of the present study, the test substance showed no androgenic activity in comparison to dihydrotestosterone in two experiments carried out independently of each other.

According to the results of the present study, the test substance showed no antiandrogenic activity in comparison to hydroxyflutamide in two experiments carried out independently of each other.