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Diss Factsheets
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EC number: 443-950-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Toxicokinetic Assessment
- Adequacy of study:
- key study
- Study period:
- Not Reported
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This toxicokinetics assessment was conducted by a capable person in a GLP facility.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- This desk-based study used existing physico-chemical, environmental fate and toxicological data to assess the toxicokinetics of the test item.
- GLP compliance:
- yes
Test material
- Details on test material:
- Idenitification of test item (as cited in study report): NALCO 01WC026/PSO
Constituent 1
- Radiolabelling:
- no
Results and discussion
Any other information on results incl. tables
The acute and dermal toxicity of NALCO 01WC026 is low, with the LD50 being > 2000 mg/kg body weight in both cases. The 28 -day toxicity study also revealed that NALCO 01WC026 has a relatively low toxicity, with a NOAEL of 1000 mg/kg/day. Therefore an extensive toxicokinetic assessment is considered of limited value. Below, an assessment of the anticipated toxicokinetic behaviour of NALCO 01WC026 is given.
The water solubility of Nalco 01WC026/PSO is high (> 1000 g/L), caused by the presence of the strongly polar phosphorous and carboxylic acid groups. The strong polarity of these groups makes it very unlikely that this compound easily passes the gastrointestinal wall. Therefore, it is to be expected that the oral bioavailability, and thus systemic exposure, of NALCO 01WC026/PSO will be low.
In the case absorption of NALCO 01WC026/PSO occurs, extensive conjugation of the carboxylic acid groups is anticipated, but also oxidation of the aliphatic groups followed by a rapid sulphation or glucuronidation may occur. The resulting metabolites, as well as the parent compound will be extensively excreted via urine and/or bile.
NALCO 01WC026/PSO will show a low volume of distribution equalling extracellular body water (approximately 0.7 litres per kg body weight). Accumulation is fatty tissues is not anticipated. The plasma protein binding is expected to be low.
Since the bioavailability of dermally applied compounds can be assumed to be zero for substances with a log Pow between -1 and over 5 or a relative molecular mass over 700, it is not expected that NALCO 01WC026 will be absorbed through the skin.
Based on the expected kinetic behaviour in the body, as described above, NALCO 01WC026/PSO will hardly be absorbed after oral administration, because of the presence of strongly polar groups in the molecule. If absorption occurs, NALCO 01WC026/PSO will be extensively metabolised in the liver. Therefore, accumulation in the body during prolonged exposure is not anticipated.
This is supported by the absence of systemic toxicity observed in both the acute and subacute toxicity studies.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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