Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
26/07/2010 - 11/08/2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Water solubility:
313.2 g/L
Temp.:
30 °C
pH:
4.95

All flasks were gel-like and subsequently unable to determine water solubility on the samples in their present form, hence the addition of 50ml of HPLC water on 02/08/10 in order to obtain a water solubility value, continuation of shaking at 30ºC.

The mean concentrations of flasks 1, 2 and 3 were used to calculate the final water solubility result. The peak amount of Aromox BW-500 in solution was apparent after 48 hours shaking at 30ºC where 496.5 g/L was detected. Samples were diluted for

analysis as soon as they were removed from the shaker at 30ºC, if left for a short amount of time (approximately 1 - 2 minutes) the samples became a white solid. The samples could not be equilibrated at room temperature prior to analysis.

Conclusions:
The water solubility was determined to be 313.2 g/L in this test, which was performed using freeze-dried C12-18 AO. Although the test samples gelled on standing, the result obtained is in line with the concentrations of C12-18 AO produced commercially.
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well reported study
Principles of method if other than guideline:
A saturated aqueous solution, based on visual observation, was prepared by mixing 10 g of lyophilised test susbtance with 15 mL of deionised water. This mixture was stirred for 24 hours at room temperature followed by centrifugation at 2500 rpm to separate undissolved solids from the aqueous phase. The concentration of the substance dissolved in the aqueous phase was analysed using a simplified DBAS method (Disulfine Blue Active Substances, Ref. Q.W. Osburn, Analytical method for Cationic Fabric Softener in Water and Wastes, JAOCS vol 59, No 10 (October 1982) p 453-457.
GLP compliance:
no
Water solubility:
409.5 g/L
Remarks on result:
other: No information on temperature or pH.
Executive summary:

The water solubility of C12 -14 AO was determined to be 409.5 g/L.

Description of key information

The water solubility is in the range of 313.2 - 409.5 g/L

Key value for chemical safety assessment

Water solubility:
313.2 g/L
at the temperature of:
30 °C

Additional information

No studies are available for C14-16 AO, however studies are available for two other members of the category – C12-14 AO and C12-18 AO. As these substances cover the chain length range of C14-16 AO it is considered appropriate to read across the values of water solubility obtained in the available studies to C14-16 AO.

In the study on C12 -14 AO [Lammens M & Rottiers A (2002)] a saturated aqueous solution, based on visual observation, was prepared by mixing 10 g of lyophilised test substance with 15 mL of deionised water. This mixture was stirred for 24 hours at room temperature followed by centrifugation at 2500 rpm to separate undissolved solids from the aqueous phase. The concentration of the substance dissolved in the aqueous phase was analysed using a simplified DBAS method. The water solubility of the substance was 409.5 g/L. No information is given in the report on stability of the lyophilised substance, but the result is in line with actual concentrations of amine oxide achieved during routine manufacturing and is considered to be reliable.

In the study on C12 -18 AO the water solubility was measured using EC Test Method A6. A water solubility of 313.2 g/L was obtained, but the samples gelled on standing and could not be equilibrated at room temperature prior to analysis. The value is considered to be valid, as C12 -18 AO is produced commercially as a 30 % w/v solution in water.

The solubility of C14-16 amine oxide is therefore considered to be in the range of 313.2 - 409.5 g/L.