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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1971
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only short abstract available, scores were not reported.
Cross-referenceopen allclose all
Reason / purpose:
reference to same study
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report Date:
1971

Materials and methods

Principles of method if other than guideline:
Equivalent to US-FHSA test method for skin irritation
GLP compliance:
no
Remarks:
pre-GLP

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: oil
Details on test material:
- Name of test material (as cited in study report): RIFM 65217 Camphor

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 2.5 to 3.4 kg bw

Test system

Type of coverage:
occlusive
Preparation of test site:
other: one site clipped and one site abraded per animal
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
Duration of treatment / exposure:
24 hours
Observation period:
72 hours
Number of animals:
6
Details on study design:
None

Results and discussion

In vivo

Irritant / corrosive response data:
Camphor was found to be moderately irritating to the rabbit skin.
Other effects:
None

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Camphor was found to be moderately irritation to rabbit skin.
Executive summary:

An acute dermal toxicity study revealed that severe edema and extensive necrosis of the rabbit skin resulted from treatment with Camphor at a single dose of 5 mL/kg bw. Therefore a primary skin irritation study was carried out to further define irritational response to this test material.

In this study, 0.5 mL of undiluted test material was applied on the clipped and abraded skin of the back of 6 rabbits. Test sites were covered with an occlusive dressing for 24 hours. Skin irritation was assessed and scored according to the Draize scale at after the removal of the patch. Scoring was repeated at 72 hours.

Camphor was found to be moderately irritation to rabbit skin.