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EC number: 235-826-2 | CAS number: 12788-93-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 9. Oct 27. Oct 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well reported guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Phosphoric acid, butyl ester
- EC Number:
- 235-826-2
- EC Name:
- Phosphoric acid, butyl ester
- Cas Number:
- 12788-93-1
- Molecular formula:
- C4H11PO4
- IUPAC Name:
- Phosphoric acid, butyl ester
- Test material form:
- other: liquid
- Details on test material:
- pH < 3
clear liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: F. Winkelmann, Borchen, Germany
- Weight at study initiation: 123.2 g
- Fasting period before study: 16 h
- Housing: in Macolon cages type III (in groups of 1-5 animals)
- Diet (e.g. ad libitum): R10 Alleindiät für Ratten, Ssniff Spezialfutter, Soest, Germany, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: 4-8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/-1°C
- Humidity (%): 60 +/- 5%
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 09.10. To: 27.10.1986
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: undiluted
- Amount of vehicle (if gavage):3.522 - 5.584 mL/kg
MAXIMUM DOSE VOLUME APPLIED: 5.584 mL/kg
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: dose setting based on results of pre-study - Doses:
- 3980, 5010 or 6310 mg/kg bw/d
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations daily after application / Weighing once weekly
- Necropsy of survivors performed: yes - Statistics:
- LD50 determination according to Litschfield and Wilcoxon
Results and discussion
- Preliminary study:
- no data
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 5 300 mg/kg bw
- 95% CL:
- > 4 609 - <= 6 095
- Mortality:
- Dose: 3980 mg/kg bw, Mortality rate: 1 / 5 (males), 0/5 (females)
Dose: 5010 mg/kg bw, Mortality rate: 5 / 5 (males), 1/5 (females)
Dose: 6310 mg/kg bw, Mortality rate: 3 / 5 (males), 3/5 (females) - Clinical signs:
- other: closed eye lid, abnormal breathing, crouched posture, piloerection, decreased motor acivity all signs were reversible within 48 h
- Gross pathology:
- thickening/necosis of intestinal and stomach mucosa
necrotic foci in liver, kidneys, spleen, pancreas and testis (sporadically)
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The median lethal dose of Phosphoric acid, butyl ester was 5300 mg per kg body weight. Based on the result of this study the test substance is not subject for labelling and classification according to regulatory requirements.
- Executive summary:
Phosphoric acid, butyl ester was tested for its acute oral toxicity potential. 5 male and 5 female rats were treated with doses of 3980, 5010 or 63100 mg/kg bw and observed for 14 days.
The median lethal dose of Phosphoric acid, butyl ester (LD50) was 5300 mg per kg body weight. Based on the result of this study the test substance is not subject for labelling and classification according to regulatory requirements.
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