Registration Dossier
Registration Dossier
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EC number: - | CAS number: 1474044-66-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 16 CFR 1500.3
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Sodium octane-1-sulphonate monohydrate
- EC Number:
- 226-195-4
- EC Name:
- Sodium octane-1-sulphonate monohydrate
- Cas Number:
- 5324-84-5
- Molecular formula:
- C8H18O3S.Na
- IUPAC Name:
- sodium octane-1-sulfonate hydrate
- Test material form:
- other: aqueous solution
- Details on test material:
- - Name of test material (as cited in study report): Sample No. 910-77
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Food was witheld overnight prior to dosing.
- Doses:
- Single dose of 5000 mg/kg
- No. of animals per sex per dose:
- Five male and five female
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: frequently on day of dosing and daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross necropsy and abnormalities recorded
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 550 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- No premature deaths were observed during the study.
- Clinical signs:
- other: No clinical signs were observed during the study.
- Gross pathology:
- No abnormalities detected.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
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