Registration Dossier
Registration Dossier
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EC number: 211-059-9 | CAS number: 628-89-7
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- R: QSAR Toolbox 3.0.1132 prediction for LOEL read across evaluation for 628-89-7
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 012
- Bibliographic source:
- QSAR Toolbox version 3
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 414 (Prenatal Developmental Toxicity Study)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-(2-chloroethoxy)ethanol
- EC Number:
- 211-059-9
- EC Name:
- 2-(2-chloroethoxy)ethanol
- Cas Number:
- 628-89-7
- Molecular formula:
- C4H9ClO2
- IUPAC Name:
- 2-(2-chloroethoxy)ethan-1-ol
- Details on test material:
- - Name of test material : 2-(2-chloroethoxy)ethanol
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss Webster
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Dose descriptor:
- NOAEL
- Effect level:
- 2 219.7 mg/kg bw/day
- Based on:
- test mat.
- Basis for effect level:
- other: developmental toxicity
Results (fetuses)
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
The prediction was based on dataset comprised from the following descriptors: NOAEL
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((("a" and "b" ) and "c" ) and ("d" and "e" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Nonionic Surfactants by US-EPA New Chemical Categories
Domain logical expression index: "b"
Similarity boundary:Target: C(Cl)COCCO
Threshold=50%,
Dice(Atom centered fragments)
Domain logical expression index: "c"
Similarity boundary:Target: C(Cl)COCCO
Threshold=50%,
Dice(Atom centered fragments)
Domain logical expression index: "d"
Parametric boundary:The target chemical should have a value of log Kow which is >= -1.48
Domain logical expression index: "e"
Parametric boundary:The target chemical should have a value of log Kow which is <= 0.569
Applicant's summary and conclusion
- Conclusions:
- The Developmental toxicity NOAEL (No observed Adverse effect level) of 2-(2-chloroethoxy)ethanol in mouse (Swiss Webster) by the oral route was observed at a dose concentration of 2219.699951172 mg/kg bw/day.
- Executive summary:
The Developmental toxicity NOAEL (No observed Adverse effect level) of 2-(2-chloroethoxy)ethanol in mouse (Swiss Webster) by the oral route was observed at a dose concentration of 2219.699951172 mg/kg bw/day.
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