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Toxicological information

Developmental toxicity / teratogenicity

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Administrative data

Endpoint:
developmental toxicity
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Predicted data
Title:
R: QSAR Toolbox 3.0.1132 prediction for LOEL read across evaluation for 628-89-7
Author:
Sustainability Support Services (Europe) AB
Year:
2012
Bibliographic source:
QSAR Toolbox version 3

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 414 (Prenatal Developmental Toxicity Study)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(2-chloroethoxy)ethanol
EC Number:
211-059-9
EC Name:
2-(2-chloroethoxy)ethanol
Cas Number:
628-89-7
Molecular formula:
C4H9ClO2
IUPAC Name:
2-(2-chloroethoxy)ethan-1-ol
Details on test material:
- Name of test material : 2-(2-chloroethoxy)ethanol
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
mouse
Strain:
Swiss Webster

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified

Results and discussion

Results: maternal animals

Effect levels (maternal animals)

Dose descriptor:
NOAEL
Effect level:
2 219.7 mg/kg bw/day
Based on:
test mat.
Basis for effect level:
other: developmental toxicity

Results (fetuses)

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Any other information on results incl. tables






The prediction was based on dataset comprised from the following descriptors: NOAEL
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

((("a" and "b" ) and "c" ) and ("d" and "e" ) )

Domain logical expression index: "a"

Referential boundary: The target chemical should be classified as Nonionic Surfactants by US-EPA New Chemical Categories

Domain logical expression index: "b"

Similarity boundary:Target: C(Cl)COCCO
Threshold=50%,
Dice(Atom centered fragments)

Domain logical expression index: "c"

Similarity boundary:Target: C(Cl)COCCO
Threshold=50%,
Dice(Atom centered fragments)

Domain logical expression index: "d"

Parametric boundary:The target chemical should have a value of log Kow which is >= -1.48

Domain logical expression index: "e"

Parametric boundary:The target chemical should have a value of log Kow which is <= 0.569

Applicant's summary and conclusion

Conclusions:
The Developmental toxicity NOAEL (No observed Adverse effect level) of 2-(2-chloroethoxy)ethanol in mouse (Swiss Webster) by the oral route was observed at a dose concentration of 2219.699951172 mg/kg bw/day.
Executive summary:

The Developmental toxicity NOAEL (No observed Adverse effect level) of 2-(2-chloroethoxy)ethanol in mouse (Swiss Webster) by the oral route was observed at a dose concentration of 2219.699951172 mg/kg bw/day.