Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Journal of Industrial Hygiene and Toxicology.
Author:
JIHTAB
Year:
1944
Bibliographic source:
Journal of Industrial Hygiene and Toxicology. 26 (1944), 269.  
Reference Type:
review article or handbook
Title:
DPIM : DKN000
Author:
Richard J. Lewis, Sr.
Year:
2007
Bibliographic source:
SAX (Sax's Handbook of Dangerous Industrial Materials); Journal of Industrial Hygiene and Toxicology. 26 (1944), 269.   

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from SAX
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(2-chloroethoxy)ethanol
EC Number:
211-059-9
EC Name:
2-(2-chloroethoxy)ethanol
Cas Number:
628-89-7
Molecular formula:
C4H9ClO2
IUPAC Name:
2-(2-chloroethoxy)ethan-1-ol
Details on test material:
- Name of test material : 2-(2-chloroethoxy)ethanol
- Molecular formula : C4H9ClO2
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: other details not available

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Acute dermal toxicity (LD50) of 2-(2-chloroethoxy)ethanol in guinea pig was found to be 3000 mg/Kg. This value indicates that 2-(2-chloroethoxy)ethanol is not toxic to skin of guinea pig
Executive summary:

Acute dermal toxicity (LD50) of 2-(2-chloroethoxy)ethanol in guinea pig was found to be 3000 mg/Kg. This value suggests that 2-(2-chloroethoxy) ethanol is not toxic to skin of guinea pig. In order to classify the substance in dermal category the lethal dose should be in the range of less than 2000 mg/kg in normal condition.