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Description of key information

The chemical 2-(2-chloroethoxy)ethanol was found to be non toxic by any of the route.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from SAX and RTECS
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Control animals:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
6 300 other: mg/kg
Based on:
test mat.
Remarks on result:
other: Details of toxic effects not reported other than lethal dose value
Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
This value suggest that the chemical 2-(2-chloroethoxy)ethanol does not exhibit acute toxicity through the oral route
Executive summary:

Acute oral toxicity value of 2-(2-chloroethoxy)ethanol in rat was found to be LD50 :6300 mg/kg. This value suggests that the chemical 2-(2-chloroethoxy)ethanol does not exhibit acute toxicity through the oral route for classification as for classification the lethal dose should be less than 2000 mg/kg.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
6 300 mg/kg bw
Quality of whole database:
K2 data from relaible handbook SAX

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Qualifier:
according to guideline
Guideline:
other: estimated data
Principles of method if other than guideline:
Prediction is done using QSAR Toolbox version 2.3
GLP compliance:
no
Test type:
other: Acute Rodent Inhalation Toxicity Test
Species:
rat
Strain:
Long-Evans
Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Duration of exposure:
8 h
Sex:
not specified
Dose descriptor:
LC50
Effect level:
133.4 other: mg/l
Based on:
test mat.
Exp. duration:
8 h





The prediction was based on dataset comprised from the following descriptors: LC50
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

(("a" and "b" ) and ("c" and "d" ) )

Domain logical expression index: "a"

Similarity boundary:Target: C(Cl)COCCO
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Similarity boundary:Target: C(Cl)COCCO
Threshold=60%,
Dice(Atom pairs)

Domain logical expression index: "c"

Parametric boundary:The target chemical should have a value of log Kow which is >= -0.529

Domain logical expression index: "d"

Parametric boundary:The target chemical should have a value of log Kow which is <= 0.516

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The 8h acute inhalation median lethal concentration (LC50) of 2-(2-chloroethoxy)ethanol in rat was estimated to be 133.4001 mg/L. This value indicates that 2-(2-chloroethoxy)ethanol does not exhibits acute toxicity by the inhalative route
Executive summary:
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The 8h acute inhalation median lethal concentration (LC50) of 2-(2-chloroethoxy)ethanol in rat was estimated to be 133.4001 mg/L . This value indicates that 2-(2-chloroethoxy)ethanol does not exhibits acute toxicity by the inhalative route. In order to classify the substance in inhalation category the lethal dose should be in the range of less than 20 mg/L in vapour condition.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LC50
Value:
133.4 mg/m³
Quality of whole database:
K2 data from QSAR model considered reliable by OECD

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from SAX
GLP compliance:
not specified
Test type:
standard acute method
Species:
guinea pig
Strain:
not specified
Sex:
not specified
Type of coverage:
not specified
Vehicle:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: other details not available
Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Acute dermal toxicity (LD50) of 2-(2-chloroethoxy)ethanol in guinea pig was found to be 3000 mg/Kg. This value indicates that 2-(2-chloroethoxy)ethanol is not toxic to skin of guinea pig
Executive summary:

Acute dermal toxicity (LD50) of 2-(2-chloroethoxy)ethanol in guinea pig was found to be 3000 mg/Kg. This value suggests that 2-(2-chloroethoxy) ethanol is not toxic to skin of guinea pig. In order to classify the substance in dermal category the lethal dose should be in the range of less than 2000 mg/kg in normal condition.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
3 000 mg/kg bw
Quality of whole database:
K2 data from relaible handbook SAX

Additional information

Acute Toxicity :

Acute toxicity : Oral

Acute oral toxicity value of 2-(2-chloroethoxy)ethanol in rat was found to be LD50 :6300 mg/kg. This value suggest that the chemical 2-(2-chloroethoxy)ethanol does not exhibit acute toxicity through the oral route

Acute toxicity : Inhalation

The 8h acute inhalation median lethal concentration (LC50) of 2-(2-chloroethoxy)ethanol in rat was estimated to be 133.4001 mg/L. This value indicates that 2-(2-chloroethoxy)ethanol does not exhibits acute toxicity by the inhalative route

No of studies reviewed for Acute toxicity: inhalation from reliable sources having Klimish rating 2

The summary if the results are presented below

 

Sr. No

Endpoint name

Value

Units

Species

1

LC50 133.4001 mg/l Rat
2 LC50  70.87939  mg/l  Mouse

 

Based on the above endpoint values it can be concluded that the substance is classified as non toxic based on classification criteria .

Acute toxicity : Dermal

Acute dermal toxicity (LD50) of 2-(2-chloroethoxy)ethanol in guinea pig was found to be 3000 mg/Kg. This value indicates that 2-(2-chloroethoxy)ethanol is not toxic to skin of guinea pig

Justification for selection of acute toxicity – oral endpoint

Acute oral toxicity value of 2-(2-chloroethoxy)ethanol in rat was found to be LD50 :6300 mg/kg. This value suggests that the chemical 2-(2-chloroethoxy)ethanol does not exhibit acute toxicity through the oral route for classification as for classification the lethal dose should be less than 2000 mg/kg.

Justification for selection of acute toxicity – inhalation endpoint

The 8h acute inhalation median lethal concentration (LC50) of 2-(2-chloroethoxy)ethanol in rat was estimated to be 133.4001 mg/L . This value indicates that 2-(2-chloroethoxy)ethanol does not exhibits acute toxicity by the inhalative route. In order to classify the substance in inhalation category the lethal dose should be in the range of less than 20 mg/L in vapour condition.

Justification for selection of acute toxicity – dermal endpoint

Acute dermal toxicity (LD50) of 2-(2-chloroethoxy)ethanol in guinea pig was found to be 3000 mg/Kg. This value suggests that 2-(2-chloroethoxy) ethanol is not toxic to skin of guinea pig. In order to classify the substance in dermal category the lethal dose should be in the range of less than 2000 mg/kg in normal condition.

Justification for classification or non-classification

The available studies indicate that 2-(2-chloroethoxy)ethanol is not classified as a acute toxicity by any of the route (oral, dermal and inhalation), according to the C & L regulation.