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Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Predicted data
Title:
R: QSAR Toolbox 3.0."Human Health Hazards#Toxicokinetics, Metabolism and Distribution#Basic Toxicokinetics" for 628-89-7
Author:
Sustainability Support Services (Europe) AB
Year:
2012
Bibliographic source:
QSAR Toolbox version 3

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD Guideline 417 (Toxicokinetics);EPA OPPTS 870.8320 (Oral/dermal pharmacokinetics)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(2-chloroethoxy)ethanol
EC Number:
211-059-9
EC Name:
2-(2-chloroethoxy)ethanol
Cas Number:
628-89-7
Molecular formula:
C4H9ClO2
IUPAC Name:
2-(2-chloroethoxy)ethan-1-ol
Details on test material:
SMILES:C(Cl)COCCO

Test animals

Species:
other: rat;mouse;human;guinea pig;rabbit
Strain:
other: Sprague-Dawley;Fischer 344;B6C3F1;not applicable;outbred strain;Wistar;"Sprague-Dawley; BDIX";New Zealand White
Sex:
not specified

Administration / exposure

Type of coverage:
other: Not applicable. in vitro study;oral: gavage;inhalation;dermal vapour;intravenous;inhalation: vapour;ip, oral and inhalation of vapour;dermal;intraperitoneal;i.v. and oral

Results and discussion

Any other information on results incl. tables

Estimation method: Takes mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

((("a" and "b")and "c")and("d" and "e"))

Domain logical expression index: "a"

Referential boundary:The target chemical should be classified as Nonionic Surfactants by US-EPA New Chemical Categories

Domain logical expression index: "b"

Similarity boundary:Target: C(Cl)COCCO
Threshold=50%,
Dice(Atom centered fragments)

Domain logical expression index: "c"

Similarity boundary:Target: C(Cl)COCCO
Threshold=50%,
Dice(Atom centered fragments)

Domain logical expression index: "d"

Parametric boundary:The target chemical should have a value of log Kow which is >= -0.692

Domain logical expression index: "e"

Parametric boundary:The target chemical should have a value of log Kow which is <= 1.55

Applicant's summary and conclusion

Conclusions:
no bioaccumulation potential based on study results
Executive summary:

No bioaccumulation potential based on study results.