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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

Three reliable studies using two species of fish.

Key value for chemical safety assessment

LC50 for freshwater fish:
159 mg/L

Additional information

Three short-term 96 -hour acute fish studies have been conducted with methyl isoamyl ketone (5 -methly-2 -hexanone). One study with fathead minnows (Pimephales promelas) was conducted as a limit test at a nominal concentration of 100 µl/L and no mortalities were observed. Two additional studies were conducted as flow-through studies with measured exposure concentrations. Rainbow trout were exposed to 5 nominal concentrations up to 100 mg/L in a flow-through system. In that study no mortality was observed up through the highest test concentration which had a mean measured concentration of 74 mg/L. The key study for this endpoint was a second flow-through study with fathead minnows that resulted in a LC50 of 159 mg/Land an NOEC for mortality of 135 mg/L (both endpoints based upon mean measured concentrations).