Registration Dossier
Registration Dossier
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EC number: 204-130-0 | CAS number: 116-17-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The results were well documented. However, indications on environmental conditions are missing. No guideline was followed and the study was not GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No precision was indicated in the study report concerning the guideline followed
- GLP compliance:
- no
- Remarks:
- Study performed before GLP
Test material
- Reference substance name:
- Triisopropyl phosphite
- EC Number:
- 204-130-0
- EC Name:
- Triisopropyl phosphite
- Cas Number:
- 116-17-6
- Molecular formula:
- C9H21O3P
- IUPAC Name:
- tris(propan-2-yl) phosphite
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): triisopropyl phosphite
- Batch: 03102
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- No data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: abraded and not abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5mL of undiluted test material
- Duration of treatment / exposure:
- 72h
- Observation period:
- 24h and 72h
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: back and flanks (4 sites exposure)
- % coverage:
- Type of wrap if used: plastic wrapping patches (2 inches sqare)
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 24h
SCORING SYSTEM: Draize &Al for edema and erythema
Results and discussion
In vivo
- Irritant / corrosive response data:
- Primary irritation score : 3.8
Any other information on results incl. tables
Primary skin irritation test – Albinos Rabbits
Animal number |
Irritation scores for abraded skin site at |
Irritation scores for abraded skin site at |
||||||
24 hours |
|
72 hours |
|
24 hours |
|
72 hours |
|
|
Erythema |
Edema |
Erythema |
Edema |
Erythema |
Edema |
Erythema |
Edema |
|
1 |
3 |
2 |
3 |
1 |
3 |
2 |
3 |
1 |
2 |
2 |
2 |
2 |
1 |
2 |
2 |
2 |
1 |
3 |
3 |
2 |
3 |
1 |
2 |
2 |
2 |
1 |
4 |
2 |
2 |
2 |
0 |
3 |
2 |
2 |
0 |
5 |
3 |
2 |
3 |
1 |
2 |
2 |
2 |
0 |
6 |
2 |
2 |
2 |
1 |
2 |
2 |
2 |
1 |
Mean |
2.5 |
2.0 |
2.5 |
0.8 |
2.3 |
2.0 |
2.2 |
0.7 |
Subtotal |
7.8 |
7.2 |
||||||
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information
- Conclusions:
- The substance is judged moderately irritating.
- Executive summary:
Based on an overal score of primary skin irritation of 3.8, the test material is judged moderately irritating.
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