Registration Dossier
Registration Dossier
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EC number: 260-126-9 | CAS number: 56358-17-9
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1987
Materials and methods
- Principles of method if other than guideline:
- The acute intraperitoneal toxicity was determined in mice
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N-(2-ethylhexyl)naphthalen-2-amine
- EC Number:
- 260-126-9
- EC Name:
- N-(2-ethylhexyl)naphthalen-2-amine
- Cas Number:
- 56358-17-9
- Molecular formula:
- C18H25N
- IUPAC Name:
- N-(2-ethylhexyl)naphthalen-2-amine
- Details on test material:
- - Name of test material (as cited in study report): N-(2-Ethylhexyl)-2-napthalinamin
- Physical state: liquid
- Analytical purity: 80%
- Impurities (identity and concentrations): 20% Shellsol
- Lot/batch No.: 79/502
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Wiga
- Weight at study initiation: mean males and females: 22-24 g
- Fasting period before study: 15-20 h before application
- Housing: no data
- Diet: Herilan MRH-Haltung, no further data
- Water: no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- VEHICLE
- Concentration in vehicle: 2 and 7 %
- Justification for choice of vehicle: none given
MAXIMUM DOSE VOLUME APPLIED:
10 ml/kg
- Doses:
- 200 and 700 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: day 0, day 2-4, day 7 and day 10-13
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 700 mg/kg bw
- Mortality:
- at 200 mg/kg bw no death occured; at 700 mg/kg bw 5/5 male and 1/5 female animals died
- Clinical signs:
- at 200 mg/kg dose level: dyspnea, apathy, spastic gait, stretching, scrubby fur and bad general condition was observed
at 700 mg/kg dose level: dyspnea, apathy, staggering, spastic gait, stretching, orange urine, scrubby fur and bad general condition was observed - Body weight:
- mean body weight males at 200 mg/kg: day 0: 24 g, day 2-4: 25 g, day 7: 30.2g, day 9-13: 31 g
mean body weight females at 200 mg/kg: day 0: 24 g, day 2-4: 27 g, day 7: 27.4g, day 9-13: 30 g
mean body weight males at 700 mg/kg: day 0: 22 g, day 2-4: 17 g, no futher weighings due to death of the animals
mean body weight females at 700 mg/kg: day 0: 22 g, day 2-4: 19.6 g, day 7: 24 g, day 9-13: 26.2 g - Gross pathology:
- no findings
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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