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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1994

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V (Ames)
GLP compliance:
yes
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
414-380-4
EC Name:
-
Cas Number:
140681-55-6
Molecular formula:
C7H14B2ClF9N2
IUPAC Name:
1-(chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium; bis(tetrafluoroboranuide)
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Method

Species / strain
Species / strain / cell type:
bacteria, other: Salmonella typhimurium: TA98, TA100, TA1535, TA1537, TA1538
Metabolic activation system:
Aroclor 1254-induced rat liver S9
Test concentrations with justification for top dose:
Concentration range in the main test (with metabolic activation): 10 ... 3333 μg/plate
Concentration range in the main test (without metabolic activation): .3 ... 5000 μg/plate
Vehicle / solvent:
Solvent: Deionised distilled water

Results and discussion

Test resultsopen allclose all
Species / strain:
other: as specified above
Metabolic activation:
with
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
cytotoxicity
Remarks:
( 3333 μg/plate)
Species / strain:
other: preliminary test
Metabolic activation:
without
Genotoxicity:
other: not applicable
Cytotoxicity / choice of top concentrations:
cytotoxicity
Remarks:
( 667 μg/plate)
Species / strain:
other: as specified above
Metabolic activation:
with
Genotoxicity:
other: not applicable
Cytotoxicity / choice of top concentrations:
cytotoxicity
Remarks:
( 3333 μg/plate)
Species / strain:
other: as specified above
Metabolic activation:
without
Genotoxicity:
other: not applicable
Cytotoxicity / choice of top concentrations:
cytotoxicity
Remarks:
(> 333 μg/plate)
Additional information on results:
Observations:
No significant increase in revertants were seen in any
strain.
Remarks on result:
other: other: preliminary test
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative with metabolic activation
positive without metabolic activation