Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Studies comparable to guideline studies, based on accepted scientific principles

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Relationships between octanol-water partition coefficient and aqueous solubility
Author:
Miller MM, Wasik P, Huang G-L, Shiu W-Y, and Mackay D
Year:
1985
Bibliographic source:
Environ. Sci. Technol., 19, 522-529
Reference Type:
review article or handbook
Title:
Selected non-heterocyclic polycyclic aromatic hydrocarbons
Author:
WHO (World Health Organization)
Year:
1998
Bibliographic source:
Environmental Health Criteria, 202, Intern. Programme on Chemical Safety (IPCS), Geneva, 1998

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
no
Type of method:
shake-flask method to: flask method
Remarks:
according to Miller et al. 1985
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
CAS-No. Concentration [%'w/w]
=========================================
Naphthalene 91-20-3 >= 35
1-Methylnaphthalene 90-12-0 >= 1
2-Methylnaphthalene 91-57-6 >= 3
Acenaphthene 83-32-9 >= 0.5
=========================================

Study design

Analytical method:
gas chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
3.4 - 4
Temp.:
25 °C
pH:
7 - 7.5
Details on results:
The logPow range of 40 - 80 % of naphthalene oil ingredients is between 3.4 and 4.0 with the estimated average of 3.6.

Any other information on results incl. tables

Summary of n-octanol-water partition coefficients (as log Pow) for key components of naphthalene oil:

CAS-No.

LogPow

Naphthalene

 91-20-3

3.351)

1-Methylnaphthalene

 90-12-0

3.871)

2-Methylnaphthalene

 91-57-6

3.861)

Acenaphthene

83-32-9

3.922)

1) Miller et al 1985

2) WHO 1998

Applicant's summary and conclusion