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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
no data
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1964

Materials and methods

Principles of method if other than guideline:
according to method of Farbenfabrik Bayer AG
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclododecanone
EC Number:
212-595-6
EC Name:
Cyclododecanone
Cas Number:
830-13-7
Molecular formula:
C12H22O
IUPAC Name:
cyclododecanone
Details on test material:
Cyclododecanone of Hüls AG as produced in 1964, "chemically pure"

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no further information

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: acetone + vegetable oil (1:10)
Details on exposure:
ADMINISTRATION: 
- Doses per time period: single dose
- Volume administered or concentration: 5 ml/kg bw
Doses:
100; 250; 500; 1000; 1250; 1500; 1500; 2000; 2500 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
- Post dose observation period: 7 days
Statistics:
LD50 by Litchfield and Wilcoxon

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 425 mg/kg bw
Mortality:
- Number of deaths at each dose:    
100, 250, 500 mg/kg bw: no deaths   
1000 mg/kg bw:  1/10 dead   
1250 mg/kg bw:  2/10 dead   
1500 mg/kg bw:  7/10 dead   
2000 mg/kg bw:  9/10 dead   
2500 mg/kg bw: 10/10 dead
Clinical signs:
- Clinical signs:   no animal of 100 mg/kg bw group   
all animals of all other groups: myospasms, spasticity, labored  respiration, signs of anesthesia
Body weight:
no data
Gross pathology:
no data
Other findings:
LD50 = 1425 (1124 - 1640) mg/kg bw

Any other information on results incl. tables

DOSE  [mg/kg bw]    MORTALITY/CLINICAL SIGNS/ANIMALS PER DOSE

------------------------------------------------------------------------

100                          0/0/10

250                          0/10/10

500                          0/10/10

1000                         1/10/10

1250                         2/10/10

1500                         7/10/10

2000                         9/10/10

2500                        10/10/10

Applicant's summary and conclusion

Conclusions:
The LD50 for acute toxicity was determined to be 1425 mg/kg bw for rats after intraperitoneal injection of cyclododecanone.
Executive summary:

An intraperitoneal acute toxicity test was conducted with cyclododecanone in rats. The LD50 was determined to be1425 mg/kg bw.