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Short-term toxicity to fish

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Description of key information

DEGDB:

Short-term toxicity to fish:

- Key study, reliability 1, OECD 203, rainbow trout - LC50 (96h) = 1.12 mg/L

- Supporting study, reliability 1, OECD 203, fathead minnow - LC50 (96h) = 1.85 mg/L

DPGDB:

Short-term toxicity to fish:

- Key study, reliability 1, OECD 203, fathead minnow - LC50 (96h) = 3.7 mg/L

- Supporting study, reliability 1, OECD 203, rainbow trout - LC50 (96h) > 3.0 mg/L

- Supporting study, reliability 2, QSAR calculation (EPIWIN-ECOSAR v1.00) - LC50 = 3.94 mg/L

- Disregarded study, reliability 3, OECD 203, fathead minnow - LL50 > 100 mg/L, NOELR = 0.8 mg/L, poor correlation of nominal levels with measured concentrations

- Disregarded study, reliability 3, OECD 203, rainbow trout - LL50 = 0.25 mg/L, NOELR = 0.06 mg/L, poor correlation of nominal levels with measured concentrations

TEGDB

Short-term toxicity to fish:

- Key study, reliability 1, OECD 203, rainbow trout - LC50 (96h) = 4.3 mg/L

- Supporting study, reliability 2, OECD 203, fathead minnow - LC50 (96h) > 5.8 mg/L

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Dose descriptor:
LC50
Effect concentration:
1.12 mg/L

Marine water fish

Marine water fish
Dose descriptor:
LC50
Effect concentration:
1.12 mg/L

Additional information

This substance is a reaction mass of dipropylene glycol dibenzoate (DPGDB), diethylene glycol dibenzoate (DEGDB) and triethylene glycol dibenzoate (TEGDB). No testing has been performed on the reaction mass itself but data are available for DPGDB, DEGDB and TEGDB individually. All the studies were performed according to international test guidelines and in compliance with GLP. They are presented below, by component. 

The acute toxicity studies were carried out on freshwater fish species (rainbow trout and fathead minnow).  The components of the reaction mass have quantitatively similar aquatic toxicity properties with all components exhibiting fish 96 hour LC50 values within the same order of magnitude. The most sensitive endpoint result obtained for these components has been used as the key value to evaluate short-term hazard and is highlighted below. A long-term toxicity to fish study is proposed for the most acutely toxic component DEGDB to be representative of the reaction mass.

The key value used in the chemical safety assessment is:

Short-term aquatic toxicity LC50 = 1.12 mg/L (DEGDB, rainbow trout)

 

 

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