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EC number: 278-388-8 | CAS number: 76199-85-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The substance is considered to be too poorly soluble for systemic uptake. This is supported by absence of toxicity in all available toxicity studies.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The toxicokinetic assessment is based on experimental data on physico-chemical properties and toxicological properties of Pigment Yellow 139 and its semi-condensate Pigment Yellow 185. Pigment Yellow 139 contains two barbituric acid moieties whereas Pigment Yellow 185 contains only one. The other moiety is the open, not fused “semi-condensate” form. An overview on the properties is given in the tables below.
As can be expected from the chemical structures, both pigments have a similar molecular weight (368 and 337 g/mol), and a similar relative density. They decompose at temperatures > 380°C prior to melting.
Both are of very low solubility in both water and octanol. From these solubilities, a Low POW of 0.31 was calculated for Pigment Yellow 139.
As the substances are so insoluble, no experimental data on abiotic hydrolysis is available.
Both molecules consist highly conjugated systems that give the molecule a rigid form.
Both general poor solubility and unflexible form impair transport across biological membranes. Absence of systemic uptake was indirectly seen by absence of toxicity in any of the available toxicity studies. Also no test-item induced coloration of internal tissues was observed upon necropsy after acute and subacute gavage dosing at the limit dose level.
Overall, uptake after ingestion, inhalation and skin contact is not expected.
Accordingly, metabolism and distribution cannot be considered and elimination is restricted to gastrointestinal passage. Inertness is also indicated from the very low toxicity upon intraperitoneal injection of a high dose (6400 mg/kg bw for PY 139 and 2000 mg/kg bw for PY 185). During the one-weak observation period, no animal died.
Should any substance be taken up, bioaccumulation is not possible since the substance is not soluble in octanol and therefore in fat.
|
PY 139 |
PY 185 |
36888-99-0 |
76199-85-4 |
|
Molecular weight |
367.27 g/mol |
337.29 g/mol |
State of the substance at 20°C and 101.3 kPa |
orange powder |
yellow powder |
Melting point |
>460°C at 1013 hPa |
Decomposes at 380°C before melting. |
Boiling point |
Not applicable (decomposes before boiling) |
Not applicable (decomposes before boiling) |
Relative densitiy |
1.73 g/cm³ |
1.50 g/cm³ |
Vapour pressure |
0.000001 hPa |
< 0.000001 hPa |
Log Pow (calculated from solubilities) |
0.31 |
|
Water solubility |
2.9 µg/L |
< 10 µg/L |
n-octanol solubility |
5.9 µg/L |
< 0.3 mg/L |
Surface tension |
Not surface active: The water solubility is below 0.1 mg/L. |
Not surface active: The water solubility is < 1 mg/L. |
Flash point |
Not relevant |
Not relevant |
Auto flammability/self-ignition temperature |
400°C at 1013 hPa |
359°C at 1013 hPa |
Flammability |
Non flammable |
Non flammable |
Explosive properties |
Non explosive |
Non explosive |
Oxidising properties |
No oxidizing properties |
No oxidizing properties |
Dissociation constant |
Not applicable |
Not applicable |
|
PY 139 |
PY 185 |
36888-99-0 |
76199-85-4 |
|
Skin and eye irritation |
Not irritating K1 |
Not irritating K2/1 |
Skin sensitzation |
Not sensitizing K1 |
Not sensitizing K1 |
acute oral tox (LD50 in mg/kg bw) |
> 10000 K2 |
> 5000 K1 |
acute dermal tox (LD50 in mg/kg bw) |
> 2500 K2 |
|
acute inhalation tox |
LC50 > 5.42 mg/L K1 |
|
Subacute toxicity |
NOAEL = 1000 K2 |
|
Bacterial mutagenicity |
Non mutagenic K2 |
Non mutagenic K1 |
Clastogenicity in vitro |
Non clastogenic K1 |
|
Mutagenicity in mammalian cells in vitro |
Non mutagenic K1 |
|
Genetic toxicitiy in vivo - micronucleus test |
Non genotoxic K1 |
|
Toxicity to reproduction (OECD 421) |
NOAEL = 1000 K1 |
|
acute toxicity upon intraperitoneal injection | No mortality at 6400 mg/kg bw | No mortality at 2000 mg/kg bw |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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