Registration Dossier

Administrative data

Description of key information

Available data on acute oral toxicity:
- isovaleraldehyde (CAS 590-86-3): LD50 = 5740 mg/kg bw in rats (BASF, 1974)
- 3-Buten-1-ol, 3-methyl- (CAS 763-32-6): LD50 > 5440 mg/kg bw in rats (BASF, 1968)
- 3-Methyl-butandiol-1,3 (CAS 2568-33-4): LD50 > 5000 mg/kg bw in rats (BASF, 1979; read across to 3-methyl-1-butanol (CAS 123-51-3))
- Rose oxide (EC 939-429-1): LD50 > 2000 mg/kg bw (Symrise, 2001; read across for DHP1, DHP2 and DHP3)
- 2H-Pyran-4-ol, tetrahydro-4-methyl-2-(2-methylpropyl)- (CAS 63500-71-0): LD50 > 2000 mg/kg bw in rats (Givaudan, 1992)
- isoprene (CAS 78-79-5): LD50 = 2125 mg/kg bw in rats (cited in OECD SIDS Dossier Isoprene, 2006)
Available data on acute inhalation toxicity:
- isovaleraldehyde (CAS 590-86-3): LC50 = 42.7 mg/L in rats (Carpenter, 1974)
- 3-Buten-1-ol, 3-methyl- (CAS 763-32-6): LC0 = 21.5 mg/l (saturated atmosphere at 20 °C, 8 h) in rats (BASF, 1968)
- 3-Methyl-butandiol-1,3 (CAS 2568-33-4): LC0 = 11.05 mg/L air (saturated vapour, 7h) in rats (BASF, 1981; read across to 3-methyl-1-butanol (CAS 123-51-3)). EU classification according to Annex VI of Directive 67/548/EEC: Xn, Harmful by inhalation; GHS classification (REGULATION (EC) No 1272/2008 (CLP)): legal classification H332 Harmful if inhaled, Acute tox. inhalation Cat. 4
- isoprene (CAS 78-79-5): LC50 = 158 mg/L air in mice (cited in OECDSIDS Dossier Isoprene, 2006)
Available data on acute dermal toxicity:
- isovaleraldehyde (CAS 590-86-3): LD50 = 2534 mg/kg bw in rabbits (Carpenter, 1974)
- 3-Methyl-butandiol-1,3 (CAS 2568-33-4): LD50 approx. 3216 mg/kg bw in rabbits (Smyth, 1969; read across to 3-methyl-1-butanol (CAS 123-51-3))
- Rose oxide (EC 939-429-1): LD50 > 5000 mg/kg (Moreno 1973; read across for DHP1, DHP2 and DHP3)
- 2H-Pyran-4-ol, tetrahydro-4-methyl-2-(2-methylpropyl)- (CAS 63500-71-0): LD50 > 2000 mg/kg bw in rabbits (Firmenich, 1985)
- isoprene (CAS 78-79-5): LD50 > 681 mg/kg bw in rats (cited in OECD SIDS Dossier Isoprene, 2006)

Key value for chemical safety assessment

Additional information

Justification for classification or non-classification

The present data on acute oral, inhalation and dermal toxicity do not fulfill the criteria laid down in 1999/45/EG and regulation (EU) 1272/2008, and therefore, a non-classification is warranted. According to UN-GHS, the UVCB substance Reaction products of 3-methylbutanal and 3-methylbut-3-en-1-ol, distillation overheads, acid-treated needs to be classified as acute oral toxicant (Category 5).