Registration Dossier
Registration Dossier
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EC number: 200-493-4 | CAS number: 60-93-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Several endpoints for acute toxicity of various organisms were available. However, Tthere are no details on the method and material available.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- ChemIDplus Advanced
- Author:
- U.S. National Library of Medicine
- Year:
- 2 013
- Bibliographic source:
- http://chem.sis.nlm.nih.gov/chemidplus/
- Report date:
- 2013
Materials and methods
- Principles of method if other than guideline:
- There are no details on the method available.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Quinine dihydrochloride
- EC Number:
- 200-493-4
- EC Name:
- Quinine dihydrochloride
- Cas Number:
- 60-93-5
- Molecular formula:
- C20H24N2O2.2ClH
- IUPAC Name:
- 6'-methoxycinchonan-9-ol dihydrochloride
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Quinine dihydrochloride
Constituent 1
Test animals
- Species:
- other: rat, mouse, rabbit
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Any other information on results incl. tables
| Organism | Test Type | Route | Reported Dose | Source |
| mouse | LD50 | oral | 660 mg/kg bw | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947. |
| rabbit | LD50 | oral | 641 mg/kg bw | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947. |
| rat | LD50 | oral | 1392 mg/kg bw | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947. |
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of quinine dihydrochloride after oral administration is 1392 mg/kg bw for rat, 660 mg/kg bw for mouse and 641 mg/kg bw for rabbit.
- Executive summary:
In the database, ChemIDplus Advanced several endpoints for acute toxicity of quinine dihydrochloride of various organisms are available. The LD50 of quinine dihydrochloride after oral administration is 1392 mg/kg bw for rat, 660 mg/kg bw for mouse and 641 mg/kg bw for rabbit.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
