Registration Dossier
Registration Dossier
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EC number: 200-493-4 | CAS number: 60-93-5
Endpoint summary
Administrative data
Description of key information
The LD50 of quinine dihydrochloride of rats after oral application is 1392 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Several endpoints for acute toxicity of various organisms were available. However, Tthere are no details on the method and material available.
- Principles of method if other than guideline:
- There are no details on the method available.
- GLP compliance:
- not specified
- Species:
- other: rat, mouse, rabbit
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of quinine dihydrochloride after oral administration is 1392 mg/kg bw for rat, 660 mg/kg bw for mouse and 641 mg/kg bw for rabbit.
- Executive summary:
In the database, ChemIDplus Advanced several endpoints for acute toxicity of quinine dihydrochloride of various organisms are available. The LD50 of quinine dihydrochloride after oral administration is 1392 mg/kg bw for rat, 660 mg/kg bw for mouse and 641 mg/kg bw for rabbit.
Reference
| Organism | Test Type | Route | Reported Dose | Source |
| mouse | LD50 | oral | 660 mg/kg bw | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947. |
| rabbit | LD50 | oral | 641 mg/kg bw | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947. |
| rat | LD50 | oral | 1392 mg/kg bw | Journal of Pharmacology and Experimental Therapeutics. Vol. 91, Pg. 157, 1947. |
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 392 mg/kg bw
- Quality of whole database:
- Several endpoints for acute toxicity of various organisms are available. However, there are no details on the method and material available.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The acute toxicity was tested on rats via oral route. From the study it is shown, that the LD50 is 1392 mg/kg bw. It is considered as harmful according to EU criteria.
Justification for classification or non-classification
The LD50 of quinine dihydrochloride of rats after oral application is 1392 mg/kg bw. According to CLP 1272/2008 criteria for oral application, LD50 > 300 mg/kg bw and < 2000 mg/kg bw, quinine hydrochloride is considered as harmful, if swallowed and has to be classified in category 4.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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