Registration Dossier
Registration Dossier
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EC number: 457-330-7 | CAS number: 66034-17-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Physical-chemical properties
The substance T-1063 FM is a physical mixture of piperazine and pyrophosphate which is provided as powder. The molecular weight of T-1063 FM is 264 Da, the sum of 86 Da for piperazine and 178 Da for pyrophosphate. T-1063 FM is soluble in water (12.24 g/l at 20°C), but not in fat (HB-307: < 1.5 mg/kg). The octanol/water partition coefficient (log Pow) could not be determined for T-1063 FM because the substance ionises in water. However, based on the good water solubility and the very low fat solubility the log Pow is expected to be < 3. The vapour pressure of T-1063 FM was determined to be below 6 x 10-6Pa.
Absorption by oral, dermal and inhalation route
The low molecular weights and the water solubility of the two constituents of T-1063 FM favour gastrointestinal absorption [ECHA 2014]. Systemic availability after oral dosing also can be deduced from the histopathological effects observed in the kidneys of female rats in the high dose group after 28 day repeated dosing.
The physical-chemical properties of T-1063 FM are considered also to favour (low) dermal absorption after topical administration [ECHA 2014].
Inhalation of any vapour from T-1063 FM is an unlikely route of human exposure, because the substance has a very low vapour pressure (< 6 x 10-6Pa at 25°C) and decomposes without boiling at high temperatures. However, exposure of workers to inhalable particles of T-1063 FM is possible, because the substance is a very fine powder with most particles below 1.2 µm. Systemic availability of T-1063 FM after inhalation is very likely based on the physical-chemical properties.
Distribution, metabolism, excretion
All available study results gave no indication regarding the distribution, metabolic pathway or excretion of T-1063 FM. Based on the good water solubility T-1063 FM is expected to be distributed in the whole body whereas bioaccumulation in fat tissue is not to be expected due to the low log Pow.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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