Registration Dossier
Registration Dossier
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EC number: 457-330-7 | CAS number: 66034-17-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- supporting study
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Partition coefficient type:
- other: standard fat - water
- Details on results:
- The calculated log partition coefficient standard fat/water (log Pfw) of the test substance is -3.91.
- Conclusions:
- Due to the very high solubility in water (12240 mg/L) and the low solubility in fat (<1.51 mg/kg standard fat) it can be concluded that the log Pow <3.
However, since the solubility T-1063FM in fat cannot be directly compared with its solubility in octanol, the latter will be determined in a separate study and the log Pow of T-1063FM will be calculated. - Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14 February - 24 June 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Version / remarks:
- Official Journal of the European Communities L383A volume 35, 29 December 1992
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- not specified
- Key result
- Remarks on result:
- other: The partition coefficient test cannot be performed for the test substance.
- Conclusions:
- The log partition coefficient n-octanol/water (log Pow) of the test substance could not be determined in this study.
Referenceopen allclose all
Description of key information
The log partition coefficient n-octanol/water (log Pow) could not be determined (EU Method A.8). However, based on high water solubility and very low solubility in fat it is concluded that log Pow is < 3.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -1
- at the temperature of:
- 20 °C
Additional information
The calculated log partition coefficient standard fat/water (log Pfw) of the test substance is -3.91.
Due to the high solubility in water (>10000 mg/L) and the low solubility in fat (<0.151 mg/100g standard fat) it can be concluded that the log Pow <3.
For the purpose of risk assessment, a logKow value of -1 is taken (minimum value which is within the boundaries of the EUSES model).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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