Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
secondary source
Title:
IUCLID DATAFILE
Author:
unknown
Year:
2000
Bibliographic source:
Esis-Database, European Chemicals Bureau

Materials and methods

Test guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3,5-dichloronitrobenzene
EC Number:
210-557-3
EC Name:
3,5-dichloronitrobenzene
Cas Number:
618-62-2
Molecular formula:
C6H3Cl2NO2
IUPAC Name:
1,3-dichloro-5-nitrobenzene

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
occlusive
Preparation of test site:
other: clipped and scarified
Vehicle:
unchanged (no vehicle)
Duration of treatment / exposure:
24
Observation period:
72
Number of animals:
4

Results and discussion

Any other information on results incl. tables

No irritation was observed after 24 and 72 hours.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU