Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-036-2 | CAS number: 2611-82-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 967
Materials and methods
- Principles of method if other than guideline:
- Aqueous solutions of test substance administered in single doses to groups of rats of both sexes by oral intubation. Animals were observed for 7 days after treatment and autopsy was carried out on those animals which died during this period and on randomly selected survivors at 7 days. Acute LD50 values with 95 % confidence limits were calculated by the method of Weil (1952).
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Acid Red 018
- IUPAC Name:
- Acid Red 018
Constituent 1
Test animals
- Species:
- other: rat and mouse
- Strain:
- other: Carworth Farm Strain E SPF (rat) and ICI Alderley Park Strain 1 SPF (mouse)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- Up to 8000 mg/kg
- No. of animals per sex per dose:
- 5/rat/sex/dose
5/mouse/sex/dose - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, colouration
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 8 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: rat and mouse
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 8 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: rat and mouse
- Mortality:
- No
- Clinical signs:
- other: No toxic signs. Lethargy for a few hours after dosing.
- Other findings:
- Slight colouration of animals; coloured material mainly excreted in faeces and to a small extent in urine.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified according to the CLP Regulation (EC 1272/2008)
- Conclusions:
- LD50 > 8000 mg/kg in rat and mouse
- Executive summary:
Method
Acute toxicity in rat and mouse dosed up to 8000 mg/kg by gavage. Observation up to 7 days and necropsy of survivors randomly selected.
Results
No deaths; lethargy for a few hours; colouration of faeces and urine.
LD50 > 8000 mg/kg.
LD0 = 8000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
