Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only abstract available, journal is in Russian.

Data source

Reference
Reference Type:
publication
Title:
Toxicity of p-terphenyl
Author:
Khromenko ZF
Year:
1972
Bibliographic source:
USSR. Nauch. Tr., Irkutsk. Med. Inst. No. 115

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
p-terphenyl
EC Number:
202-205-2
EC Name:
p-terphenyl
Cas Number:
92-94-4
Molecular formula:
C18H14
IUPAC Name:
1,1':4',1''-terphenyl
Details on test material:
The study was done on one of the isomers (p-terphenyl) which is only present in the registration substance in minor concentrations.

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Details on inhalation exposure:
Concentrations:
- 3 mg/m3
- 35 mg/m3
Analytical verification of doses or concentrations:
not specified

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
After chronic exposure to 35 mg/m3 air, functional and morphological changes in the organs were observed. At a concentration of 3 mg/m3 this was not the case. The approximated maximum permissible concentration in air of working areas is therefor recommended to be 5 mg/m3.