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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
Chronic toxic effects of polyphenyl mixtures
Author:
Young G, Petkau A, Hoogstraten J
Year:
1969
Bibliographic source:
American Industrial Hygiene Association Journal, Volume 30, Issue 1, pp 7-19

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Santowax OM
IUPAC Name:
Santowax OM
Constituent 2
Reference substance name:
Terphenyl
EC Number:
247-477-3
EC Name:
Terphenyl
Cas Number:
26140-60-3
Molecular formula:
C18H14
IUPAC Name:
2-phenyl-1,1'-biphenyl; 3-phenyl-1,1'-biphenyl; 4-phenyl-1,1'-biphenyl
Details on test material:
Santowax OM is a commercial organic coolant containing 4.7% biphenyl, 64.1 % o-terphenyl, 24% m-terphenyl and 6.1% p-terphenyl.

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: feed
Frequency of treatment:
daily
Details on study design:
daily dietary intake of 350 mg/kg

Results and discussion

Results of examinations

Details on results:
at 350 mg/kg bw, irreversible interstitial nephritis with scarring was observed

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Executive summary:

After daily intake of 350 mg/kg (or more) Santowax OM (wich is a mixture of mainly ortho- and meta- terphenyl), used as a coolant, severe and to some extent irreversible chemical nephrosis and interstitial nephritis was found in rats following prolonged ingestion.